Oligopeptides

from Wikipedia, the free encyclopedia
A tripeptide (such as Val - Gly - Ala ) with a
green marked N-terminal α-amino acid residue (in the example: L -valine ) and a blue- marked C-terminal α-amino acid residue (in the example: L -alanine )
Glutathione tripeptide with a green -labeled N-terminal γ-L-glutamyl residue and blue labeled C-terminal glycyl residue
A tetrapeptide (such as Val - Gly - Ser - Ala ) with a
green marked N-terminal α-amino acid residue (in the example: L -Valin ) and a blue- marked C-terminal α-amino acid residue (in the example: L - Alanine )

Oligopeptides are peptides in which fewer than ten amino acids - mostly α-amino acids - are chemically linked to one another via peptide bonds . According to other sources, peptides which are built up from three to ten amino acid units are classified as oligopeptides.

Occurrence

Many oligopeptides are naturally occurring and have very specific physiological properties, e.g. B. as peptide hormones , kinins , amanitins , toxins or peptide antibiotics . The latter also often occur as cyclopeptides , which can contain L- amino acid residues.

Manufacture and creation

Degradation reactions of polypeptides yield oligopeptides hydrolytically or enzymatically . Also solid phase syntheses lead to oligopeptides.

See also

Individual evidence

  1. ↑ Hans-Dieter Jakubke, Hans Jeschkeit: Amino acids, Peptides, Proteins , Verlag Chemie, Weinheim, pp. 97-103, 1982, ISBN 3-527-25892-2 .
  2. ↑ Otto-Albrecht Neumüller (Ed.): Römpps Chemie-Lexikon. Volume 4: M-Pk. 8th revised and expanded edition. Franckh'sche Verlagshandlung, Stuttgart 1985, ISBN 3-440-04514-5 , p. 2894.