Pentapeptides

A linear pentapeptide (such as β-Ala - Trp - Met - Asp - Phe ) with a green labeled N-terminal β-amino acid residue (in the example: β-alanine ) and a blue- labeled C-terminal α-amino acid residue ( in the example: L- phenylalanine ).

Pentagastrin - a linear pentapeptide ( β-Ala - Trp - Met - Asp - Phe ) with a red- marked BOC group on the N-terminal β-amino acid residue.

A pentapeptide is a peptide from the group of oligopeptides . It is made up of five amino acids that are linked to one another via peptide bonds .

construction

A distinction is made between linear pentapeptides (contain four peptide bonds ) and cyclic pentapeptides . In the case of cyclic pentapeptides, the cyclization is based on a fifth peptide bond or another intramolecular covalent bond .

Examples

• Pentagastrin is used clinically for the diagnosis of gastric secretion.
• Enterostatin from the intestine is involved in the feeling of satiety.
• Opiorphin is an endorphin .
• Enkephalins are another class of endogenous opioids in addition to endorphins and dynorphins .
• Cilengitide is a blood vessel growth inhibitor that is used to treat tumors .

See also

• Dipeptide
• Tripeptide
• Tetrapeptides
• Hexapeptides
• Heptapeptides
• Decapeptide

Individual evidence

1. ↑ Hans-Dieter Jakubke, Hans Jeschkeit: amino acids, peptides, proteins , Verlag Chemie, Weinheim, pp. 310-311, 1982, ISBN 3-527-25892-2 .