Opiorphin
| Opiorphin | ||
|---|---|---|
|
||
| Properties of human protein | ||
| Mass / length primary structure | 5 amino acids | |
| Precursor | PRL1 | |
| Identifier | ||
| Gene name | PRL1 | |
| External IDs | ||
Opiorphin is an endogenous pentapeptide with the amino acid sequence Gln-Arg-Phe-Ser-Arg.
In experiments with rats, the analgesic effect ( analgesic potency ) was 3 to 6 times higher than that of morphine . In humans it is found in saliva . In further animal experiments in 2010 the analgesic and antidepressant effects were confirmed, as well as the absence of most opioid side effects (intestinal paralysis, increased dose) and antidepressant side effects (overexcitability, sedation, memory disorders).
literature
- Body produces powerful pain killers ( Memento from December 16, 2013 in the Internet Archive ). Netzeitung.de, November 14, 2006, accessed on September 6, 2010.
- Anne Wisner, Evelyne Dufour, Michaël Messaoudi, Amine Nejdi, Audrey Marcel, Marie-Noelle Ungeheuer, Catherine Rougeot: Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways . In: Proceedings of the National Academy of Sciences . tape 103 , no. 47 , 2006, p. 17979-17984 , doi : 10.1073 / pnas.0605865103 , PMID 17101991 .
Individual evidence
- ↑ Entry on opioid peptides. In: Römpp Online . Georg Thieme Verlag, accessed on November 1, 2017.
- ↑ Marie de Chalup: Opiorphin - a promising analgesic and antidepressant molecule. Scientific Department, French Embassy in the Federal Republic of Germany, press release from September 10, 2010 from the Science Information Service (idw-online.de), accessed on September 13, 2009.