Pentagastrin
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Non-proprietary name | Pentagastrin | |||||||||||||||||||||
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Molecular formula | C 37 H 49 N 7 O 9 S | |||||||||||||||||||||
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Mechanism of action |
Cholecystokinin B receptor agonist |
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Molar mass | 767.89 g · mol -1 | |||||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Pentagastrin is a synthetic oligopeptide that has the same effect as gastrin when given parenterally . It stimulates the secretion of gastric acid , pepsin , and the intrinsic factor .
Pentagastrin binds to the cholecystokinin B receptor, which is expressed by many cells in the brain. Activation of this receptor triggers the phospholipase C second messenger system. When given intravenously , panic attacks and gastrointestinal complaints up to and including vomiting can sometimes be triggered.
application
It is routinely used to perform the pentagastrin test in medical diagnostics. Pentagastrin is also used in a stimulation test to increase serotonin levels and causes symptoms of carcinoid syndrome . It provokes flushing and can help diagnose patients who complain of episodic flushing but have normal or only slightly elevated levels of markers specific to carcinoid syndrome. It has also been used to stimulate ectopic gastric mucosa to detect Meckel's diverticulum by nuclear medicine imaging.
pharmacology
After intravenous administration, pentagastrin has a half-life of about 10 minutes and is mainly eliminated by the liver.
Trade names
ICI 50.123, Gastrodiagnost, Peptavlon
Individual evidence
- ↑ a b Datasheet Pentagastrin, ≥95% (HPLC), powder from Sigma-Aldrich , accessed on November 1, 2016 ( PDF ).
- ↑ Joan M. Braganza, K. Herman, Pauline Hine, G. Kay: The effect of pentagastrin on peptic secretion in man ; In: J Physiol . 1979 April; 289: 9-16. PMC 1281354 (free full text).
- ↑ I. Grelle, H. Jahn, P. Doyle, KH Nerlich, C. Düren, M. Luster, C. Reiners: The most frequently reported complaints during the pentagastrin and calcium stimulation test on 50 test subjects (PDF; 12 kB), MTRA poster, 46th annual meeting of the DGN, 23. – 26. April 2008.