Phosphatidate phosphatases
| Phosphatidate phosphatases | ||
|---|---|---|
| Identifier | ||
| Gene name (s) | PPAP2 , PPAP2 , PPAP2 , LPPR1 , LPPR2 , LPPR3 , LPPR4 , LPPR5 | |
| Enzyme classification | ||
| EC, category | 3.1.3.4 , phosphatase | |
| Response type | Hydrolysis of a phosphoric acid ester bond | |
| Substrate | sn -3 phosphatidate + H 2 O | |
| Products | sn-1,2-diacylglycerol + phosphate | |
| Occurrence | ||
| Parent taxon | Creature | |
Phosphatidate phosphatase (PAP) (also: lipid phosphate phosphohydrolases ) are enzymes which phosphate residues of phosphatidic hydroxide. This makes them indispensable for the biosynthesis of triglycerides . Several enzymes with this function can also split off phosphate from other phospholipids and are therefore important in regulating signal transduction using lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P).
Phosphatidate phosphatases occur in all living things. Eight paralogous proteins are known in humans, not all of which have an enzyme function and which are expressed in different tissue types. The most important isozymes , which also have regulatory capabilities due to their broad spectrum of activity, have the abbreviations PAP2-α, -β and -γ.
Catalyzed reaction
+ H 2 O ⇒ 
+ P i
Phosphatidate is hydrolyzed to diacylglycerin .
Individual evidence
- ↑ UniProt O14494 , UniProt O14495 , UniProt O43688
- ↑ Kai M, Wada I, Imai S, Sakane F, Kanoh H: Cloning and characterization of two human isozymes of Mg2 + -independent phosphatidic acid phosphatase . In: J. Biol. Chem. . 272, No. 39, September 1997, pp. 24572-8. PMID 9305923 .
Web links
- Gopinathrao / reactome.org: Conversion of Phosphatidic Acid to Diacylglycerol