Pleiotropy (pharmacology)

Pleiotropy (Gr. Pleio = 'full' and trop = 'twist', 'twist') describes in pharmacology the presence of several effects in an active ingredient . These can be side effects or effects that can lead to off-label use .

Statins, for example, have a pleiotropic effect because their effect reduces mortality more than is evident from the effect of lowering cholesterol levels .

Individual evidence

^ Davignon J: Beneficial cardiovascular pleiotropic effects of statins . In: Circulation . 109, No. 23 Suppl 1, June 2004, pp. III39-43. doi : 10.1161 / 01.CIR.0000131517.20177.5a . PMID 15198965 .
↑ Rod Flower; Humphrey P. Rang; Maureen M. Dale; Knight, James M .: Rank & Dale's pharmacology . Churchill Livingstone, Edinburgh 2007, ISBN 0-443-06911-5 .
↑ F. Olivieri, I. Mazzanti, AM Abbatecola, R. Recchioni, F. Marcheselli, AD Procopio, R. Antonicelli: Telomere / Telomerase system: a new target of statins pleiotropic effect? In: Curr Vasc Pharmacol . (2012), Volume 10, No. 2, pp. 216-224. PMID 22022767 .

[Davignon-1] Davignon J: Beneficial cardiovascular pleiotropic effects of statins . In: Circulation . 109, No. 23 Suppl 1, June 2004, pp. III39-43. doi : 10.1161 / 01.CIR.0000131517.20177.5a . PMID 15198965 .

[rang-2] Rod Flower; Humphrey P. Rang; Maureen M. Dale; Knight, James M .: Rank & Dale's pharmacology . Churchill Livingstone, Edinburgh 2007, ISBN 0-443-06911-5 .

[3] F. Olivieri, I. Mazzanti, AM Abbatecola, R. Recchioni, F. Marcheselli, AD Procopio, R. Antonicelli: Telomere / Telomerase system: a new target of statins pleiotropic effect? In: Curr Vasc Pharmacol . (2012), Volume 10, No. 2, pp. 216-224. PMID 22022767 .