Pocket protein family

The pocket protein family is a family of proteins that act as tumor suppressors . It is named after a binding pocket with which you can bind your target molecules. They play an important role in the cell cycle by interacting with the transcription factors of the E2F family and are regulated by their expression and by phosphorylation . They can also be linked by a number of viral oncogenes , which may explain their role in cancer development.

There are three proteins in the pocket protein family:

Individual evidence

↑ Tim Carter Humphrey, Gavin Brooks: Cell cycle control: mechanisms and protocols . Springer, 2005, ISBN 978-1-59259-857-1 , pp. 120 .
↑ D. Cobrinik: Pocket protein and cell cycle control. In: Oncogene . Volume 24, Number 17, April 2005, pp. 2796-2809, doi : 10.1038 / sj.onc.1208619 . PMID 15838516 . (Review).

[1] Tim Carter Humphrey, Gavin Brooks: Cell cycle control: mechanisms and protocols . Springer, 2005, ISBN 978-1-59259-857-1 , pp. 120 .

[pmid15838516-2] D. Cobrinik: Pocket protein and cell cycle control. In: Oncogene . Volume 24, Number 17, April 2005, pp. 2796-2809, doi : 10.1038 / sj.onc.1208619 . PMID 15838516 . (Review).