Retinoblastoma-like protein 1

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Retinoblastoma-like protein 1

Existing structural data : 1h28

Properties of human protein
Mass / length primary structure 1068 amino acids
Isoforms 2
Identifier
Gene names RBL1  ; PRB1; CP107; MGC40006; p107
External IDs
Occurrence
Homology family RB1
Parent taxon Eukaryotes
Orthologue
human mouse
Entrez 5933 19650
Ensemble ENSG00000080839 ENSMUSG00000027641
UniProt P28749 Q3U1D4
Refseq (mRNA) NM_002895 NM_011249
Refseq (protein) NP_002886 NP_035379
Gene locus Chr 20: 35.06 - 35.16 Mb Chr 2: 156.84 - 156.9 Mb
PubMed search 5933 19650

The Retinoblastoma-like protein 1 (p107, RBL1) is a protein in eukaryotes , which in the regulation of the cell cycle is involved. It is directly involved in the formation of heterochromatin at the beginning of cell division by controlling the chromatin structure and the methylation of the histones . RBL1 is believed to be a tumor suppressor .

RBL1 is phosphorylated in the S / M phase transition and dephosphorylated in the G1 phase of the cell cycle. The RB1 protein and the RBL1 protein can form complexes with the E1A protein of the adenoviruses and the large T antigen of SV40 . The large T-antigen only binds to RB1 and RBL1 if they are dephosphorylated . Both proteins can inhibit the transcription of genes that regulate the cell cycle and have so-called E2F binding sites in their regulatory genes .

RBL1 is similar in sequence and function to RB1 . Because of the similarity that RBL1 has with RB1, it is assumed that RBL1 is also a tumor suppressor. So far, two different transcripts of the gene have been discovered that correspond to two isoforms of the gene product.

See also

further reading

  • Faha B, Ewen ME, Tsai LH, et al. : Interaction between human cyclin A and adenovirus E1A-associated p107 protein. in: Science vol. 255.5040 pg. 87-90 (1992) PMID 1532458
  • Ewen ME, Xing YG, Lawrence JB, Livingston DM: Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. in: Cell vol. 66.6 pg. 1155-64 (1991) PMID 1833063
  • Datta PK, Raychaudhuri P, Bagchi S: Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. in: Mol. Cell. Biol. Vol. 15.10 pg. 5444-52 (1995) PMID 7565695
  • Zhu L, Zhu L, Xie E, Chang LS: Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. in: Mol. Cell. Biol. Vol. 15.7 pg. 3552-62 (1995) PMID 7791762
  • Sardet C, Vidal M, Cobrinik D, et al. : E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA vol. 92.6 pg. 2403-7 (1995) PMID 7892279
  • Kim YW, Otterson GA, Kratzke RA, et al. : Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. in: Mol. Cell. Biol. Vol. 14.11 pg. 7256-64 (1994) PMID 7935440
  • Ginsberg D, Vairo G, Chittenden T, et al. : E2F-4, a new member of the E2F transcription factor family, interacts with p107. in: Genes Dev. vol. 8.22 pg. 2665-79 (1994) PMID 7958924
  • Beijersbergen RL, Kerkhoven RM, Zhu L, et al. : E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. in: Genes Dev. vol. 8.22 pg. 2680-90 (1994) PMID 7958925
  • Beijersbergen RL, Hijmans EM, Zhu L, Bernards R: Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. in: EMBO J. vol. 13.17 pg. 4080-6 (1994) PMID 8076603
  • Dyson N, Dembski M, Fattaey A, et al. : Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. in: J. Virol. vol. 67.12 pg. 7641-7 (1993) PMID 8230483
  • Zhu L, van den Heuvel S, Helin K, et al. : Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. in: Genes Dev. vol. 7.7A pg. 1111-25 (1993) PMID 8319904
  • Ikeda MA, Jakoi L, Nevins JR: A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. in: Proc. Natl. Acad. Sci. USA vol. 93.8 pg. 3215-20 (1996) PMID 8622916
  • Xiao ZX, Ginsberg D, Ewen M, Livingston DM: Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. in: Proc. Natl. Acad. Sci. USA vol. 93.10 pg. 4633-7 (1996) PMID 8643455
  • Vidal M, Brachmann RK, Fattaey A, et al. : Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. in: Proc. Natl. Acad. Sci. USA vol. 93.19 pg. 10315-20 (1996) PMID 8816797
  • Shao Z, Siegert JL, Ruppert S, Robbins PD: Rb interacts with TAF (II) 250 / TFIID through multiple domains. in: Oncogene vol. 15.4 pg. 385-92 (1997) PMID 9242374
  • Verona R, Moberg K, Estes S, et al. : E2F activity is regulated by cell cycle-dependent changes in subcellular localization. in: Mol. Cell. Biol. Vol. 17.12 pg. 7268-82 (1997) PMID 9372959
  • Trimarchi JM, Fairchild B, Verona R, et al. : E2F-6, a member of the E2F family that can behave as a transcriptional repressor. in: Proc. Natl. Acad. Sci. USA vol. 95.6 pg. 2850-5 (1998) PMID 9501179
  • Sterner JM, Dew-Knight S, Musahl C, et al. : Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. in: Mol. Cell. Biol. Vol. 18.5 pg. 2748-57 (1998) PMID 9566894
  • Woitach JT, Zhang M, Niu CH, Thorgeirsson SS: A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. in: Nat. Genet. vol. 19.4 pg. 371-4 (1998) PMID 9697699
  • Veal E, Eisenstein M, Tseng ZH, Gill G: A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. in: Mol. Cell. Biol. Vol. 18.9 pg. 5032-41 (1998) PMID 9710587

Individual evidence

  1. ↑ UniProt entry
  2. ↑ Entrez Gene: RBL1 retinoblastoma-like 1 (p107) . Retrieved February 3, 2011.