Tumor suppressor genes

Tumor suppressor genes are parts of the genetic makeup of a cell that express so-called tumor suppressors , i.e. proteins that control the cell cycle or trigger apoptosis . The tumor suppressor genes thus control cell growth and proliferation and suppress the transition from normal cell growth behavior to unchecked tumor growth . They have a braking function with regard to unbridled cell growth and are therefore sometimes referred to as anti-ioncogenes .

An inactivating loss-of-function mutation , e.g. B. by a frameshift mutation , splicesite mutation , or the partial or complete deletion of the tumor suppressor gene causes a defect or deficiency of this tumor suppressor protein and thus increases the probability of tumor formation. In this sense, inactivated tumor suppressor genes have an effect comparable to that of activated oncogenes .

literature

• Wolfgang Hiddemann , Claus Rainer Bartram : Oncology: Part 1: Epidemiology - Pathogenesis - Basic principles of therapy . Springer, 2009, ISBN 3-540-79724-6 , pp. 90 ff .
• John N. Weinstein, Eric A. Collisson, Gordon B. Mills, et al. a .: The Cancer Genome Atlas Pan-Cancer analysis project. In. Nature Genetics. Volume 45, 2013, pp. 1113–1120, doi: 10.1038 / ng.2764 .
• T. Jacks: Tumor suppressor gene mutations in mice. In: Annual review of genetics. (Annu Rev Genet.) 1996, Volume 30, pp. 603-636, doi: 10.1146 / annurev.genet.30.1.603 .

Web links

• P. Altmeyer: The online encyclopedia of dermatology, venereology, allergology and environmental medicine. Keyword: tumor suppressor genes. ( Memento from February 16, 2016 in the Internet Archive )
• Scientists Tie Several Cancers to Common 'Oncogene Engine'
• US Department of Health and Human Services - National Institutes of Health - National Cancer Institute - National Human Genome Research Institute (NIH): The Cancer Genome Atlas (TCGA). On: cancergenome.nih.gov ; accessed on February 6, 2017.