Poligeenan

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Poligeenan (synonym degraded carrageenan , dCGN) is a partially hydrolysed carrageenan from red algae of the family Rhodophyceae .

properties

Poligeenan (CAS No. 53973-98-1) is a mixture of polysaccharides of different lengths, which are of low viscosity in aqueous solutions and have a high number of sulfate groups that act as chelators . The degraded k-carrageenan contained in it has cytotoxic effects, whereas the undegraded one does not. The degraded carrageenan of about 40 kDa is more toxic than that of 10 kDa. Poligeenan is as a possible carcinogen (possibly carcinogenic to humans) classified the stage 2B.

Manufacturing

Poligeenan is produced from carrageenan, a sulfated polygalactan , by acid hydrolysis for up to six hours at a pH value of one and temperatures of around 90 ° C. The hydrolysis is carried out up to an average molecular weight of 10 to 20 kDa .

application

Poligeenan is used as a viscous chelator for barium sulfate suspensions, which are used for X-ray diagnostics of the swallowing process. The viscosity makes it easier to swallow the suspension and delays the precipitation of the barium sulfate particles from the suspension.

Individual evidence

  1. ↑ SH Ariffin, WW Yeen, IZ Abidin, RM Abdul Wahab, ZZ Ariffin, S. Senafi: Cytotoxicity effect of degraded and undegraded kappa and iota carrageenan in human intestine and liver cell lines. In: BMC complementary and alternative medicine. Volume 14, 2014, ISSN  1472-6882 , p. 508, doi : 10.1186 / 1472-6882-14-508 , PMID 25519220 , PMC 4320596 (free full text).
  2. ↑ C. Benard, A. Cultrone, C. Michel, C. Rosales, JP Segain, M. Lahaye, JP Galmiche, C. Cherbut, HM Blottière: Degraded carrageenan causing colitis in rats induces TNF secretion and ICAM-1 upregulation in monocytes through NF-kappaB activation. In: PloS one. Volume 5, number 1, 2010, ISSN  1932-6203 , p. E8666, doi : 10.1371 / journal.pone.0008666 , PMID 20072622 , PMC 2800179 (free full text).
  3. ↑ IARC Monograph Volume 31, Supp 7. (1987). Agents Classified by the IARC Monographs, Volumes 1-112 .