Pyrrolidine alkaloids

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Pyrrolidine , the basic chemical structure of the pyrrolidine alkaloids

The pyrrolidine alkaloids are natural substances that are chemically derived from pyrrolidine .

Occurrence

Alkaloids with a pyrrolidine partial structure are usually further subdivided according to their occurrence and their biogenetic origin. Hygrin and cuscohygrin were isolated from the leaves of the coca bush , while (-) - codonopsinin was isolated from the clematis-like tiger bell .

  • Coca bush ( Erythroxylum coca ) with leaves and fruits

  • Clematis tiger bell ( Codonopsis clematidea )

Representative

The most important representatives of the pyrrolidine alkaloids include hygrin and cuscohygrin . Another representative is (-) - codonopsinin . Furthermore include Ruspolinon , Norruspolinon and Norruspolin to this alkaloid group.

  • (+) - hygrin

  • (-) - codonopsinin

  • (-) - ruspolinone

  • ( R ) -Norruspoline

properties

Many plants containing cuscohygrin are used as sedatives or narcotics in folk medicine of various peoples .

Individual evidence

  1. ↑ Entry on pyrrolidine. In: Römpp Online . Georg Thieme Verlag, accessed on May 21, 2020.
  2. ^ A b H. Latscha, U. Kazmaier: Chemistry for Biologists . 4th edition. Springer Spectrum, Berlin Heidelberg 2016, ISBN 978-3-662-47783-0 , p. 682 .
  3. ↑ a b J. Reddy, B. Rao: A Short, Efficient and Stereoselective Total Synthesis of a pyrrolidines alkaloid ( -) - Codonopsinine . In: The Journal of Organic Chemistry . tape 72 , no. 6 , 2007, p. 2224-2227 , doi : 10.1021 / jo061940q .
  4. ↑ F. Roessler, D. Ganzinger, S. Johne, E. Schöpp, M. Hesse: Ruspolia hypercrateriformis MR: Isolation and structure elucidation of new pyrrolidine alkaloids. 169. Communication on organic natural substances . In: Helvetica Chimica Acta . tape 61 , no. 3 , 1978, p. 1200–1206 , doi : 10.1002 / hlca.19780610336 .
  5. ↑ Entry on Cuscohygrin. In: Römpp Online . Georg Thieme Verlag, accessed on May 21, 2020.

Web links

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