Radiologically isolated syndrome

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A radiologically isolated syndrome (RIS) means the chance during a symptom-free people by means of magnetic resonance imaging demonstrated (MRI) damage (lesion) of one or more places in the brain and / or spinal cord , by virtue of the location and shape consistent with a demyelinating injury in multiple sclerosis ( MS) is. There must be no other explanation for the damage. According to the 2017 revision of the McDonald criteria, multiple sclerosis can only be diagnosed as soon as symptoms have first appeared and the diagnostic criteria have been met.

Symptoms appeared within five years in around a third of those affected who had lesions seen on MRI. Risk factors for the development of multiple sclerosis from a radiologically isolated syndrome are a young age, a high cerebral lesion load, infratentorial or spinal lesions, contrast-enhancing lesions, the detection of oligoclonal bands in the cerebrospinal fluid and pathological visual evoked potentials (VEP).

See also

literature

  • Therein T. Okuda: Radiologically Isolated Syndrome. In: Neuroimaging Clinics of North America. 27, 2017, pp. 267–275, doi : 10.1016 / j.nic.2016.12.008 .

Individual evidence

  1. ↑ a b c Alan J. Thompson, Brenda L. Banwell et al. a .: Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. In: The Lancet Neurology . 17, 2018, p. 162, doi : 10.1016 / S1474-4422 (17) 30470-2 .
  2. ↑ O. Aktas, MP Wattjes, M. Stangel, H.-P. Hartung: Diagnosis of Multiple Sclerosis: Revision of the McDonald Criteria 2017. In: Der Nervenarzt . 89, 2018, pp. 1344-1354, PMID 29876600 , doi : 10.1007 / s00115-018-0550-0 .
  3. ↑ Therein T. Okuda, Aksel Siva, Orhun Kantarci et al .: Radiologically Isolated Syndrome: 5-Year Risk for an Initial Clinical Event. In: PLoS ONE . 9, 2014, doi : 10.1371 / journal.pone.0090509 .