Rebound (medicine)

The term rebound or Absetzeffekt (of Engl. Rebound , rebound ') referred to in medicine the amplified recurrence of symptoms of a disease after discontinuation of drug treatment drug .

properties

These effects or phenomena are based, among other things, on the fact that during treatment with an antagonist there is an increase in the number of receptors on which the previously ingested medicinal substance acted. The consequence of this increase is an increased sensitivity to the body's own messenger substances. Examples are tachycardia after discontinuation of beta blockers , increased formation of gastric acid after discontinuation of proton pump inhibitors , rhinitis medicamentosa after discontinuation of certain nasal sprays or anxiety disorders after discontinuation of benzodiazepines . A rebound occurs, among other things, when administering antidotes that have a shorter plasma half-life than the poison (e.g. naloxone ).

See also

• Ceiling effect

Individual evidence

1. ^ NG Hunfeld, WP Geus, EJ Kuipers: Systematic review: Rebound acid hypersecretion after therapy with proton pump inhibitors. In: Alimentary pharmacology & therapeutics. Volume 25, Number 1, January 2007, pp. 39-46, doi : 10.1111 / j.1365-2036.2006.03171.x . PMID 17229219 .
2. ^ G. Chouinard: Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound. In: The Journal of clinical psychiatry. Volume 65 Suppl 5, 2004, pp. 7-12, PMID 15078112 .

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