Rosenthal fiber

Histology. Numerous eosinophilic (reddish colored) rose half fibers in the section of a pilocytic astrocytoma.
Hematoxylin-eosin stain . 400x magnification.

Worm- shaped eosinophilic inclusions are referred to as Rosenthal fibers , which can be detected in fine tissue in astrocytic cells and were first described by the pathologist Werner Rosenthal in 1898.

Rosenthal fibers are found in reactively altered astrocytes. They are also a typical characteristic of pilocytic astrocytoma and the very rare Alexander disease . Ultrastructural are intermediate filaments with attached electron-dense material. Immunohistochemically , rose half fibers are positive for alpha B-crystallin, ubiquitin and (to varying degrees) for GFAP .

swell

• Peiffer, Schröder & Paulus: Neuropathology. Springer, Berlin (2002) ISBN 3540413332 page 351.

Individual evidence

1. ↑ Rosenthal: About a peculiar swelling of the spinal cord complicated with syringomyelia. Contributions to pathological anatomy and general pathology 1898; 23: 111–43
2. ↑ Wippold et al .: Neuropathology for the neuroradiologist: Rosenthal fibers. AJNR Am J Neuroradiol. 2006; 27: 958-61. PMID 16687524 full text
3. ↑ Tomokane et al .: Rosenthal fibers share epitopes with alpha B-crystallin, glial fibrillary acidic protein, and ubiquitin, but not with vimentin. Immunoelectron microscopy with colloidal gold. In: Am J Pathol , 1991; 138 (4): 875-85. PMID 1707236

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