Sarcoglycans

Sarcoglycans form a group of transmembrane proteins (α-, β-, γ-, δ-, ε- and ζ-sarcoglycan), which are present in the sarcolemma of the muscle cells of striated muscles. Together with dystroglycan, they form the membrane-spanning component of the dystrophin-glycoprotein complex, which links F-actin of the cytoskeleton with elements of the extracellular matrix. This serves to stabilize the sarcolemma and protect it from shear forces. A defect in the sarcoglycans (e.g. through mutation of the coding genes) leads to sarcoglycanopathies . Thus, mutations in the genes for Sarcoglycan α, β, γ, or δ (not ε) to the limb- lead. While sarcoglycans α, β, γ, δ, and ζ occur mainly in muscles, sarcoglycans ε are found in various organs such as the liver, kidneys, lungs, spleen and, above all, in nerve cells.

Genes

• SGCA
• SGCB
• SGCD
• SGCE
• SGCG
• SGCZ

Individual evidence

1. ↑ SGCZ sarcoglycan zeta [Homo sapiens (human)] - Genes - NCBI. Retrieved September 10, 2017 . 
2. ↑ MeSH Browser. Retrieved September 10, 2017 . 
3. ↑ SGCE - epsilon-sarcoglycan - Homo sapiens (Human) - SGCE gene & protein. Retrieved September 10, 2017 . 
4. ↑ SGCE sarcoglycan epsilon [Homo sapiens (human)] - Genes - NCBI. Retrieved September 10, 2017 . 
5. ↑ Genetics Home Reference: SGCE gene. Retrieved September 10, 2017 .