Serodiscordance

A sero-discordant relationship is a sexual relationship in which one partner is infected with HIV and the other is not. This is in contrast to seroconcordant relationships in which both partners have the same HIV status, i.e. both partners are either HIV positive or HIV negative. Serodiscordance contributes to the spread of HIV / AIDS, especially in sub-Saharan countries like Lesotho . Serodiscordance results from an unequal serostatus, for example between two partners or twins , one of whom is HIV-positive and the other HIV-negative.

Daily pre-exposure prophylaxis (PrEP) with TDF ( tenofovir disoproxil fumarate ) or TDF-FTC (with emtricitabine ) reduces the risk of HIV transmission in sero-discordant couples.

In couples where the man is infected with HIV but the woman is not, the use of sperm preparation techniques in conjunction with insemination or in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) has been shown to be very effective in order to the seroconversion of uninfected women and their fetuses to avoid. The Sperm washing can be used to reduce the risk of HIV transmission in HIV-positive men to lower as the infection takes place rather by the seminal fluid than the sperm itself. An Italian study from 2005 of 567 treated serodiscordant couples found no horizontal (for the woman) or vertical (for the child) HIV seroconversion.

Web links

Wiktionary: Serodiscordance  - explanations of meanings, word origins , synonyms, translations

Individual evidence

1. ↑ CC Makwe, OF Giwa-Osagie: sexual and reproductive health in HIV serodiscordant couples. In: African journal of reproductive health. Volume 17, Number 4 Spec No, December 2013, pp. 99-106, PMID 24689321 (review).
2. ↑ Stephan Dressler, Matthias Wienold, AIDS Pocket Dictionary , March 7, 2013, Springer-Verlag, ISBN 978-3-642-80257-7 , p. 131
3. ↑ Lori A. Nacius, Judy Levison et al. a .: Serodiscordance and Disclosure Among HIV-Positive Pregnant Women in the Southwestern United States. In: AIDS Patient Care and STDs. 27, 2013, p. 242, doi: 10.1089 / apc.2012.0416 .
4. ↑ Flore Huber-Geismann, Antiretroviral Pre-Exposure Prophylaxis Reduces the Risk of HIV Transmission in Serodiscordant Couples , evimed. Retrieved May 8, 2019.
5. ^ Karen Schneider, Richard T. Gray, David P. Wilson: A Cost-effectiveness Analysis of HIV Preexposure Prophylaxis for Men Who Have Sex With Men in Australia . In: Clinical Infectious Diseases . tape 58 , no. 7 , April 1, 2014, p. 1027-1034 , doi : 10.1093 / cid / cit946 , PMID 24385445 .
6. ↑ Human immunodeficiency virus (HIV) and infertility treatment: a committee opinion , Ethics Committee of the American Society for Reproductive Medicine, doi: 10.1016 / j.fertnstert.2015.04.004 , 104, 2015. Retrieved May 8, 2019.
7. ↑ About.com> HIV and Sperm Washing. By Mark Cichocki, RN December 18, 2009

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !