Suction blister technique

The suction blister technique ("suction blister technique ") is a technique for skin transplantation , through which chronic skin damage such as poorly healing leg ulcers and white spot disease (vitiligo) can be treated. It is a technically simpler alternative to split-thickness skin - or full-thickness skin grafts.

Using a suction device or a modified injection syringe, the lamina lucida of the skin is detached from the underlying layers in order to separate the epidermis from the subcutaneous tissue. The applied negative pressure of approx. 200-300 mmHg causes bubbles within two to three hours . The roof of the bladder is then cut off in a sterile manner and transferred to the target area. Since only the epidermis is detached, the wounds (so-called erosions ) do not bleed and later heal without scars. The technique can be performed under local anesthesia.

The suction blister technique is also used in pharmacological research to measure drug concentrations in the skin. It was developed for this purpose in 1967 by the Finnish dermatologist Urpo Kiistala .

Web links

Dermatologic Surgery Made Easy . Jaypee Brothers Publishers, New Delhi 2008, ISBN 978-81-8061-747-8 , pp. 77–82 ( limited preview in Google Book Search).

Individual evidence

↑ Devendra K. Gupta: Microskin Grafting for Vitiligo . Springer, Dordrecht, et al. 2009, ISBN 978-1-84882-604-5 , pp. 19th ff ., doi : 10.1007 / 978-1-84882-605-2 ( limited preview in Google Book search).
^ U Costanzo, Streit, M; Braathen, LR: Autologous suction blister grafting for chronic leg ulcers . In: J Eur Acad Dermatol Venereol . 22, No. 1, 2007, pp. 7-10. doi : 10.1111 / j.1468-3083.2007.02148.x . PMID 18181967 .
↑ Robert L. Bronaugh, Howard I. Maibach: Percutaneous Absorption: Drugs - Cosmetics - Mechanisms - Methodology: Drugs - Cosmetics - Mechanisms - Methodology . Third ed. Taylor & Francis, New York 1999, ISBN 0-8247-1966-2 , pp. 349 ( limited preview in Google Book search).
↑ U. Kiistala: Suction blister device for separation of viable epidermis from dermis. In: Journal of Investigative Dermatology . Volume 50, Number 2, February 1968, pp. 129-137, ISSN 0022-202X . PMID 4868034 .

[Microskin_Grafting_for_Vitiligo-1] Devendra K. Gupta: Microskin Grafting for Vitiligo . Springer, Dordrecht, et al. 2009, ISBN 978-1-84882-604-5 , pp. 19th ff ., doi : 10.1007 / 978-1-84882-605-2 ( limited preview in Google Book search).

[costanzo-2] U Costanzo, Streit, M; Braathen, LR: Autologous suction blister grafting for chronic leg ulcers . In: J Eur Acad Dermatol Venereol . 22, No. 1, 2007, pp. 7-10. doi : 10.1111 / j.1468-3083.2007.02148.x . PMID 18181967 .

[BronaughMaibach1999-3] Robert L. Bronaugh, Howard I. Maibach: Percutaneous Absorption: Drugs - Cosmetics - Mechanisms - Methodology: Drugs - Cosmetics - Mechanisms - Methodology . Third ed. Taylor & Francis, New York 1999, ISBN 0-8247-1966-2 , pp. 349 ( limited preview in Google Book search).

[PMID4868034-4] U. Kiistala: Suction blister device for separation of viable epidermis from dermis. In: Journal of Investigative Dermatology . Volume 50, Number 2, February 1968, pp. 129-137, ISSN 0022-202X . PMID 4868034 .