Tetracyclic antidepressant
Tetracyclic antidepressants are psychotropic drugs that are used to treat depressive disorders . They represent a further development of the tricyclic antidepressants , to which they are structurally and pharmacologically similar. In their chemical structure they do not have three but four ( condensed ) carbon rings. In the case of mianserin and mirtazapine, their effect is presumably based on a blockade of presynaptic α 2 receptors and postsynaptic 5-HT 2 and 5-HT 3 receptors. A certain inhibition of the reuptake, especially of noradrenaline from the synaptic cleft , may play a role.
Active ingredients
literature
Müller WE: Mechanisms of action of tricyclic and tetracyclic antidepressants . In: Pharm Our Time . 37, No. 3, 2008, pp. 198-204. doi : 10.1002 / pauz.200800262 . PMID 18446901 .
