Thrombocytosis

Classification according to ICD-10
D75.9	Thrombocytosis
D47.3	Essential thrombocythemia
ICD-10 online (WHO version 2019)

One speaks of thrombocytosis when the number of platelets ( thrombocytes ) in the blood exceeds the normal range (see blood count ). A distinction is made between reactive thrombocytosis, which is caused by other underlying diseases, and essential thrombocythemia , which is an independent bone marrow disease and is counted among the myeloproliferative diseases .

Reactive thrombocytosis can occur

after a splenectomy
for malignant tumors
during or after cytostatic chemotherapy
after acute blood loss ,
with chronic iron deficiency , but also
in chronic inflammatory diseases (e.g. Crohn's disease , rheumatic diseases ).

Thrombocytosis after severe injuries

After severe injuries, an increase in platelet counts of over 1,000,000 per µl is observed in up to 1.4% of cases. Whether this increases the risk of complications such as thrombosis is controversial. Likewise, there is no agreement as to whether in these cases of thrombocytosis therapy z. B. with ASS is necessary.

Individual evidence

↑ Z. Saadi, K. Inaba, G. Barmparas, A. Salim, P. Talving, D. Plurad, D. Green, D. Demetriades: Extreme thrombocytosis in trauma patients: are antiplatelet agents the answer? In: The American surgeon. Volume 75, Number 10, October 2009, ISSN 0003-1348 , pp. 1020-1024, PMID 19886157 .
Jump up ↑ CN Harrison, D. Bareford, N. Butt, P. Campbell, E. Conneally, M. Drummond, W. Erber, T. Everington, AR Green, GW Hall, BJ Hunt, CA Ludlam, R. Murrin, C. Nelson-Piercy, DH Radia, JT Reilly, J. Van der Walt, B. Wilkins, MF McMullin: Guideline for investigation and management of adults and children presenting with a thrombocytosis. In: British Journal of Hematology . Volume 149, Number 3, May 2010, ISSN 1365-2141 , pp. 352-375, doi : 10.1111 / j.1365-2141.2010.08122.x , PMID 20331456 (review).
Jump up ↑ CN Harrison, D. Bareford, N. Butt, P. Campbell, E. Conneally, M. Drummond, W. Erber, T. Everington, AR Green, GW Hall, BJ Hunt, CA Ludlam, R. Murrin, C. Nelson-Piercy, DH Radia, JT Reilly, J. Van der Walt, B. Wilkins, MF McMullin: Guideline for investigation and management of adults and children presenting with a thrombocytosis. In: British Journal of Hematology . Volume 149, Number 3, May 2010, ISSN 1365-2141 , pp. 352-375, doi : 10.1111 / j.1365-2141.2010.08122.x , PMID 20331456 (review).

[1] Z. Saadi, K. Inaba, G. Barmparas, A. Salim, P. Talving, D. Plurad, D. Green, D. Demetriades: Extreme thrombocytosis in trauma patients: are antiplatelet agents the answer? In: The American surgeon. Volume 75, Number 10, October 2009, ISSN 0003-1348 , pp. 1020-1024, PMID 19886157 .

[2] Jump up ↑ CN Harrison, D. Bareford, N. Butt, P. Campbell, E. Conneally, M. Drummond, W. Erber, T. Everington, AR Green, GW Hall, BJ Hunt, CA Ludlam, R. Murrin, C. Nelson-Piercy, DH Radia, JT Reilly, J. Van der Walt, B. Wilkins, MF McMullin: Guideline for investigation and management of adults and children presenting with a thrombocytosis. In: British Journal of Hematology . Volume 149, Number 3, May 2010, ISSN 1365-2141 , pp. 352-375, doi : 10.1111 / j.1365-2141.2010.08122.x , PMID 20331456 (review).

[3] Jump up ↑ CN Harrison, D. Bareford, N. Butt, P. Campbell, E. Conneally, M. Drummond, W. Erber, T. Everington, AR Green, GW Hall, BJ Hunt, CA Ludlam, R. Murrin, C. Nelson-Piercy, DH Radia, JT Reilly, J. Van der Walt, B. Wilkins, MF McMullin: Guideline for investigation and management of adults and children presenting with a thrombocytosis. In: British Journal of Hematology . Volume 149, Number 3, May 2010, ISSN 1365-2141 , pp. 352-375, doi : 10.1111 / j.1365-2141.2010.08122.x , PMID 20331456 (review).