Trans-activation response element

The trans-activation response element is part of the genetic code of the HI virus .

Sequence of the TAR region. The view shows the TAR RNA sequence of the HIV-1 virus. Complementary base pairs are represented by a colon. The 5 'and 3' ends are highlighted in red. The region recognized by the Tat protein is shown in green.

The TAR element has two functions. On the one hand, it serves as a recognition region for the viral Tat protein, which regulates the translation of the virus components. On the other hand, it serves as a precursor of micro-RNA , which influences the regulation of the host proteins. Above all, the apoptosis of the affected cells is inhibited.

Individual evidence

↑ Dominique L. Ouellet, Isabelle Plante, Patricia Landry, Corinne Barat, Marie-Ève Janelle, Louis Flamand, Michel J. Tremblay, Patrick Provost: Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element . In: Nucleic Acids Research . tape 36 , no. 7 , 2008, p. 2353-2365 , doi : 10.1093 / nar / gkn076 .
↑ Zachary Klase, Rafael Winograd, Jeremiah Davis, Lawrence Carpio, Richard Hildreth, Mohammad Heydarian, Sidney Fu, Timothy McCaffrey, Eti Meiri, Mila Ayash-Rashkovsky, Shlomit Gilad, Zwi Bentwich, Fatah Kashanchi: HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression . In: Retrovirology . tape 6 , no. 18 , 2009, doi : 10.1186 / 1742-4690-6-18 .

Web links

English review article about Tat with a detailed part about the TAR element - Los Alamos Laboratories .

[1] Dominique L. Ouellet, Isabelle Plante, Patricia Landry, Corinne Barat, Marie-Ève Janelle, Louis Flamand, Michel J. Tremblay, Patrick Provost: Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element . In: Nucleic Acids Research . tape 36 , no. 7 , 2008, p. 2353-2365 , doi : 10.1093 / nar / gkn076 .

[2] Zachary Klase, Rafael Winograd, Jeremiah Davis, Lawrence Carpio, Richard Hildreth, Mohammad Heydarian, Sidney Fu, Timothy McCaffrey, Eti Meiri, Mila Ayash-Rashkovsky, Shlomit Gilad, Zwi Bentwich, Fatah Kashanchi: HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression . In: Retrovirology . tape 6 , no. 18 , 2009, doi : 10.1186 / 1742-4690-6-18 .