Transcriptional interference
Transcriptional interference or the English term " transcriptional interference " describes a form of gene regulation . For the repression of a gene there is a second promoter in front of the promoter of the gene. If this is active, the RNA polymerase attaches to it and synthesizes non-coding RNA . This transcription thus creates a kind of promoter competition , since the promoter behind it is not accessible to the RNA polymerase. This prevents the actual gene from being transcribed.
This form of gene regulation has been described in the fruit fly Drosophila melanogaster as well as in yeast and may also occur in other organisms . It also appears to be tissue specific and could have arisen from retrotransposons .
Technical article
- Ingo H. Greger, Agustin Aranda, Nick Proudfoot: Balancing transcriptional interference and initiation on the GAL7 promoter of Saccharomyces cerevisiae. In: Proceedings of the National Academy of Sciences of the United States of America . PNAS. 18, 97, 15, July 2000, ISSN 0027-8424 , pp. 8415-8420, online (PDF; 280 KB) .
- Caroline Conte, Bernard Dastugue, Chantal Vaury: Promoter competition as a mechanism of transcriptional interference mediated by retrotransposons. In: The EMBO Journal . 21, 2002, ISSN 0261-4189 , pp. 3908-3916, doi : 10.1093 / emboj / cdf367 .