Trypsinogen
Trypsinogen [Trypsin + gene.] (Physiol.) Is the secreted (secreted) precursor ( proenzyme ) of the pancreatic enzyme trypsin . Like chymotrypsinogen , proelastase and other enzymes, it is secreted in an inactive form.
meaning
The inactive proenzyme trypsinogen is the precursor of the protein-splitting digestive enzyme trypsin. Trypsinogen is secreted in the pancreas and activated in the duodenum by a membrane-bound enteropeptidase . This is done by proteolytic cleavage, in which the enteropeptidase cleaves the hexapeptide (Val-Asp-Asp-Asp-Asp-Lys) from the inactive enzyme precursor trypsinogen. The protein-splitting enzyme trypsin is in turn involved in digestive processes by catalyzing the proteolytic cleavage of trypsinogen into trypsin and is responsible for the proteolytic cleavage of chymotrypsin and procarboxypeptidase.
Diseases
Mutations of the cationic trypsinogen are found in patients with chronic non-alcoholic pancreatitis, although a clear autosomal dominant inheritance could not be documented. Other point mutations that were found in the screening of relatives of index patients are L104P, R116C and C139F. However, the importance of these trypsinogen mutants should not be overestimated, since no mutation could be detected in 69.4 percent of the index patients from families with hereditary pancreatitis . As before, a careful clinical examination and taking a family history are indicated if there is any suspicion, and not a search for genetic variants.
Individual evidence
- ↑ Niels Teich, Nadine Bauer, Joachim Mössner u. a .: Mutational screening of patients with nonalcoholic chronic pancreatitis. Identification of further trypsinogenic variants . In: American Journal of Gastroenterology , Vol. 97 (2002), Issue 2, pp. 341-346, ISSN 0002-9270 , PMID 11866271 .