Vogt-Koyanagi-Harada syndrome

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Poliosis VKHS.JPG
Classification according to ICD-10
H30.8 Other chorioretinitis
ICD-10 online (WHO version 2019)

The Vogt-Koyanagi-Harada syndrome is a multisystemic disease, a T-cell mediated autoimmune response against melanocytes is based.

The disease, which usually begins between the ages of 20 and 50 and primarily affects more pigmented population groups, is characterized by recurrent aseptic meningitis , iridocyclitis, vitiligo and loss of eyelashes after a non-specific prodromal stage that resembles a viral infection . The diagnostic criteria were revised in 1999. The diagnosis is made clinically, depending on the extraocular manifestations as complete, incomplete, or likely. The treatment is carried out successfully with high-dose steroids, possibly longer-term with additional immunosuppressants such as ciclosporin . The longer-term prognosis for vision is good if the diagnosis is made early and aggressive treatment is used. An animal model of the disease has existed since 2008.

The disease is named after Alfred Vogt , Yoshizo Koyanagi and Einosuke Harada . A synonym is Yugé syndrome (after T. Yugé).

Individual evidence

  1. ↑ MM Lavezzo, VM Sakata et al. a .: Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. In: Orphanet Journal of Rare Diseases. Volume 11, March 2016, p. 29, doi : 10.1186 / s13023-016-0412-4 , PMID 27008848 , PMC 4806431 (free full text) (review).
  2. ↑ K. Yamaki, S. Ohono: Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia) . In: Ophthalmic Res. Volume 40 , no. 3-4 , 2008, pp. 129-35 , doi : 10.1159 / 000119863 , PMID 18421226 .
  3. ↑ Vogt-Koyanagi-Harada syndrome at whonamedit.com; Retrieved October 6, 2012.

literature