Vroman effect

The Vroman effect , named after Leo Vroman is, an effect of when adsorption of proteins from the blood serum occurs at a surface. The proteins with the highest mobility (small proteins) reach the surface first; however, they are displaced by the following proteins, which have a lower mobility but a higher affinity for the surface. A typical example is fibrin , which is adsorbed on biopolymers and is later displaced by other proteins. This leads to a decrease in the fibrinogen level in the blood serum.

literature

• L. Vroman: Effect of Adsorbed Proteins on the Wettability of Hydrophilic and Hydrophobic Solids . (PDF) In: Nature . 196, No. 196, November 3, 1962, pp. 476-477. doi : 10.1038 / 196476a0 .
• CH Bamford, Stuart L. Cooper, T. Tsurutta: The Vroman Effect . VSP, 1992. ISBN 9789067641395 .

Individual evidence

1. ↑ P. Somasundaran: Encyclopedia of Surface and Colloid Science , Volume 7, CRC Press, ISBN 9780849396151 . P. 5240.