William Spence
William Spence is the name of the following people:
- William Spence (mathematician) (1777–1815), Scottish mathematician
- William Spence (entomologist) (1782-1860) British entomologist
- William Spence (politician) (1846–1926), Australian trade unionist and politician
- William Blundell Spence (1814–1900), English painter and art dealer