Wind-up phenomenon

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The wind-up phenomenon describes spinal processes that lead to central hypersensitivity or hyperalgesia and thus to a persistent increase in pain . The role of the N -methyl- D -aspartate receptors ( NMDA receptors ) is seen as the most important factor in its development.

Diseases in which wind-up phenomena are likely to play a role include anesthesia dolorosa , fibromyalgia and chronic idiopathic facial pain .

Web links

• Neuropathic Pain - Classifications and Treatment Options from: Pharmazeutische Zeitung online, issue 42/2004