Mode of action
The mode of action describes the events and processes that result from an organism's exposure to a chemical , from the biochemical interaction of a substance with a cell, through functional or anatomical changes in the cell, to an impact on health . However, the name is not defined uniformly. In the Guidance on information requirements and chemical safety assessment of ECHA relevant to human health for the determination of dose or concentration requires disclosures for action. Chemicals can be categorized based on their mode of action, even if the process has not yet been finally clarified at the molecular level.
example
If the mechanism at the molecular level is binding to DNA , the mode of action is e.g. B. influencing the transcription or replication of DNA.
literature
- KS Crump: Use of threshold and mode of action in risk assessment. In: Critical reviews in toxicology. Volume 41, Number 8, September 2011, ISSN 1547-6898 , pp. 637-650, doi : 10.3109 / 10408444.2011.566258 , PMID 21718086 .
Individual evidence
- ^ Mechanisms and mode of dioxin action . US EPA . Retrieved December 7, 2014.
- ↑ JC Lambert, JC Lipscomb: Mode of action as a determining factor in additivity models for chemical mixture risk assessment. In: Regulatory toxicology and pharmacology: RTP. Volume 49, Number 3, December 2007, ISSN 0273-2300 , pp. 183-194, doi : 10.1016 / j.yrtph.2007.07.002 , PMID 17804132 .
- ↑ ECHA : Guidance on information requirements and chemical safety assessment - Chapter R.8: Characterization of dose [concentration] - response for human health , 2012.
- ^ Wai-Leung Ng, Krystyna M. Kazmierczak, Gregory T. Robertson, Raymond Gilmour, Malcolm E. Winkler: Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyzes of Streptococcus Pneumoniae R6 Challenged with Sublethal Concentrations of Translation Inhibitors . In: Journal of Bacteriology . 185, No. 1, 2003, pp. 359-370. doi : 10.1128 / JB.185.1.359-370.2003 .