Paul Modrich

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Paul L. Modrich

Paul Lawrence Modrich (born June 13, 1946 in Raton , New Mexico ) is an American biochemist and geneticist . In 2015 he was awarded the Nobel Prize in Chemistry “for the mechanistic studies on DNA repair ” together with Tomas Lindahl and Aziz Sancar .

Life

Paul Modrich

Modrich grew up in a small town in northern New Mexico. He studied at the Massachusetts Institute of Technology , where he received a Bachelor of Science degree in biology in 1968 . He then did his doctorate at Stanford University , where he received a PhD in biochemistry in 1973 . As a post-doctoral student he was at Harvard University in 1973/74. In 1974 he became an assistant professor in chemistry at the University of California, Berkeley and in 1976 at Duke University , where he was made a full professorship in biochemistry in 1988. From 1994 he was also a researcher at the Howard Hughes Medical Institute .

Modrich received the Pfizer Award in Enzyme Chemistry in 1983 , the National Institutes of Health's Merit Award in 1986 (whose Career Development Award he received in 1978), the Charles S. Mott Prize in 1996, and the Pasarow Award in 1998. He is a member of the National Academy of Sciences , the National Academy of Medicine, and the American Academy of Arts and Sciences .

Modrich clarified the molecular mechanisms of DNA repair during cell division, the so-called mismatch repair (base mismatch repair ).

Web links

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