SLC26A8: Difference between revisions

SLC26A8
Identifiers
Aliases	SLC26A8, SPGF3, TAT1, solute carrier family 26 member 8
External IDs	OMIM: 608480; MGI: 2385046; HomoloGene: 27095; GeneCards: SLC26A8; OMA:SLC26A8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,024,868 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,909,207 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; secondary oocyte; ; sperm; ; blood; ; bone marrow cells; ; nucleus accumbens; ; Brodmann area 9; ; prefrontal cortex; ; hypothalamus; ; caudate nucleus;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; superior frontal gyrus; ; cerebellar cortex; ; medial vestibular nucleus; ; inferior colliculus; ; ventromedial nucleus; ; cerebellar vermis; ; suprachiasmatic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	anion transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; oxalate transmembrane transporter activity; protein binding; chloride channel activity; chloride transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	flagellated sperm motility; cell differentiation; oxalate transport; sulfate transport; regulation of membrane potential; regulation of intracellular pH; ion transport; anion transport; multicellular organism development; bicarbonate transport; meiosis; transmembrane transport; spermatogenesis; sperm capacitation; chloride transport; chloride transmembrane transport; sulfate transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	116369
	224661
	ENSG00000112053
	ENSMUSG00000036196
	Q96RN1
	Q8R0C3
	NM_001193476; NM_052961; NM_138718
	NM_001290320; NM_146076
	NP_001180405; NP_443193; NP_619732
	NP_001277249
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 09:53, 5 December 2020

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.^[5]^[6]^[7]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.^[7]

Interactions

SLC26A8 has been shown to interact with RACGAP1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112053 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036196 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
^ ^a ^b "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
^ Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495.
Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655.
Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
Mocellin R, Bühlmeyer K (1975). "Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension". Eur J Cardiol. 3 (3): 205–11. PMID 1183472.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112053 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036196 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11834742-5] Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.

[pmid11829495-6] Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.

[entrez-7] "Entrez Gene: SLC26A8 solute carrier family 26, member 8".

[pmid11278976-8] Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

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@@ Line 1: / Line 1: @@
 {{Infobox_gene}}
-'''Testis anion transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC26A8'' [[gene]].<ref name="pmid11834742">{{cite journal | vauthors = Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J | title = Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 14246–54  | date = Apr 2002 | pmid = 11834742 | pmc =  | doi = 10.1074/jbc.M111802200 | doi-access = free }}</ref><ref name="pmid11829495">{{cite journal | vauthors = Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP | title = Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney | journal = Genomics | volume = 79 | issue = 2 | pages = 249–56  | date = Feb 2002 | pmid = 11829495 | pmc =  | doi = 10.1006/geno.2002.6689 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC26A8 solute carrier family 26, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116369| accessdate = }}</ref>
+'''Testis anion transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC26A8'' [[gene]].<ref name="pmid11834742">{{cite journal | vauthors = Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J | title = Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 14246–54  | date = Apr 2002 | pmid = 11834742 | doi = 10.1074/jbc.M111802200 | doi-access = free }}</ref><ref name="pmid11829495">{{cite journal | vauthors = Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP | title = Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney | journal = Genomics | volume = 79 | issue = 2 | pages = 249–56  | date = Feb 2002 | pmid = 11829495 | doi = 10.1006/geno.2002.6689 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC26A8 solute carrier family 26, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116369}}</ref>
 == Function ==
@@ Line 18: / Line 18: @@
 * {{cite journal | vauthors = Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J | title = Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure | journal = Mol. Hum. Reprod. | volume = 11 | issue = 2 | pages = 129–32 | year = 2005 | pmid = 15579655 | doi = 10.1093/molehr/gah140 | doi-access = free }}
 * {{cite journal | vauthors = Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G | title = Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 20309–15 | year = 2001 | pmid = 11278976 | doi = 10.1074/jbc.M011740200 | doi-access = free }}
-* {{cite journal | vauthors = Mocellin R, Bühlmeyer K | title = Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension | journal = Eur J Cardiol | volume = 3 | issue = 3 | pages = 205–11 | year = 1975 | pmid = 1183472 | doi =  }}
+* {{cite journal | vauthors = Mocellin R, Bühlmeyer K | title = Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension | journal = Eur J Cardiol | volume = 3 | issue = 3 | pages = 205–11 | year = 1975 | pmid = 1183472 }}
 {{refend}}

Revision as of 09:53, 5 December 2020

Function

Interactions

References

Further reading