TBC1D4

TBC1D4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QYB
Identifiers
Aliases	TBC1D4, AS160, NIDDM5, TBC1 domain family member 4
External IDs	OMIM: 612465; MGI: 2429660; HomoloGene: 45451; GeneCards: TBC1D4; OMA:TBC1D4 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	75,482,169 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	101,846,627 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; thoracic diaphragm; ; vastus lateralis muscle; ; parotid gland; ; caput epididymis; ; corpus epididymis; ; left adrenal gland; ; triceps brachii muscle; ; deltoid muscle; ; body of tongue;
	Top expressed in
	temporal muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; interventricular septum; ; extraocular muscle; ; parotid gland; ; lymph node; ; intercostal muscle; ; cerebellar vermis; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	endomembrane system; intracellular anatomical structure; cytoplasm; cytosol; vesicle;
Biological process	vesicle-mediated transport; negative regulation of vesicle fusion; cellular response to insulin stimulus; regulation of vesicle fusion; activation of GTPase activity; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	9882
	210789
	ENSG00000136111
	ENSMUSG00000033083
	O60343
	Q8BYJ6
	NM_001286658; NM_001286659; NM_014832
	NM_001081278; NM_173380
	NP_001273587; NP_001273588; NP_055647
	NP_001074747; NP_001391600; NP_001391601; NP_001391602; NP_001391603
	Wikidata
View/Edit Human	View/Edit Mouse

Template:PBB Controls

TBC1 domain family, member 4, also known as TBC1D4 and AS160, is a human gene.^[5]

The 160 kD protein product was first discovered in a screen for novel substrates of the serine-threonine kinase Akt, which phosphorylates AS160 after insulin stimulation.^[6] Insulin stimulation of fat and muscle cells results in translocation of the glucose transporter GLUT4 to the plasma membrane, and this translocation process is dependent on phosphorylation of AS160.^[7] The role of AS160 in GLUT4 translocation is mediated by its GTPase activating domain, which interacts with Rab proteins in vesicle formation. Specifically, AS160 activates RAB2A, RAB8A, RAB10 and RAB14.^[8]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136111 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033083 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TBC1D4 TBC1 domain family, member 4".
^ Kane S, Sano H, Liu SC; et al. (2002). "A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain". J. Biol. Chem. 277 (25): 22115–8. doi:10.1074/jbc.C200198200. PMID 11994271. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^ Sano H, Kane S, Sano E; et al. (2003). "Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation". J. Biol. Chem. 278 (17): 14599–602. doi:10.1074/jbc.C300063200. PMID 12637568. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^ Mîinea CP, Sano H, Kane S; et al. (2005). "AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain". Biochem. J. 391 (Pt 1): 87–93. doi:10.1042/BJ20050887. PMID 15971998. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)

References

Further reading