Somatomedin
Somatomedin is a group of hormones that is produced, when stimulated by somatotropin (STH), to promote cell growth and division.[1] In this way, they mediate the effect of somatotropin (also known as growth hormone [2]).
They have similar biological effects to somatotropin.
Somatomedins also stimulates Somatostatin production. Somatostatin suppresses growth hormone release. So, levels of somatomedin and growth hormone are controlled via negative feedback. When somatomedin levels are high, they reduce growth hormone levels by stimulating somatostatin production. Growth hormone stimulates the liver to produce somatomedins. So, a high level of somatomedins means a high level of growth hormone. And when this happens, somatomedins lower the level of growth hormone by stimulating somatostatin.
Somatomedinsa also suppress growth hormone release in the pituitary. This is another example of negative feedback.
Three forms include:
- somatomedin A, which is another name for insulin-like growth factor 2
- somatomedin B, which is derived from vitronectin[3]
- somatomedin C, which is another name for insulin-like growth factor 1
References
- ^ Template:EMedicineDictionary
- ^ Template:EMedicineDictionary
- ^ Zhou A (2007). "Functional structure of the somatomedin B domain of vitronectin". Protein Science. 16 (7): 1502. doi:10.1110/ps.072819107. PMC 2206693. PMID 17567740.
External links
- Somatomedins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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