Enamelin

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Enamelin
Enamelin
Identifiers
Symbol	Enamelin
Pfam	PF15362
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ENAM
Identifiers
Aliases	ENAM, AIH2, AI1C, ADAI, enamelin
External IDs	OMIM: 606585; MGI: 1333772; HomoloGene: 9698; GeneCards: ENAM; OMA:ENAM - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	70,646,824 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	88,653,908 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; vastus lateralis muscle; ; striated muscle tissue; ; biceps brachii; ; kidney; ; deltoid muscle; ; corpus epididymis; ; gallbladder; ; gastrocnemius muscle; ; left ventricle;
	Top expressed in
	molar; ; tracheobronchial tree; ; intestinal villus; ; inferior colliculus; ; superior colliculus; ; primary motor cortex; ; medulla oblongata;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of tooth enamel; protein binding;
Cellular component	extracellular region; endoplasmic reticulum lumen; extracellular matrix;
Biological process	odontogenesis of dentin-containing tooth; biomineral tissue development; amelogenesis; regulation of cell morphogenesis; ameloblast differentiation; positive regulation of enamel mineralization; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	10117
	13801
	ENSG00000132464
	ENSMUSG00000029286
	Q9NRM1
	O55196
	NM_031889; NM_001368133
	NM_017468
	NP_114095; NP_001355062
	NP_059496
	Wikidata
View/Edit Human	View/Edit Mouse

Enamelin is an enamel matrix protein, that in humans is encoded by the ENAM gene.^[5]^[6] It is part of the non amelogenins which comprise 10% of the total enamel matrix proteins.^[7] It is one of the key proteins which are involved in amelogenesis (enamel development).

Template:PBB Summary

Structure

Words

Function

Words

Clinical significance

Words

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029286 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mardh CK, Backman B, Holmgren G, Hu JC, Simmer JP, Forsman-Semb K (Apr 2002). "A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)". Hum Mol Genet. 11 (9): 1069–74. doi:10.1093/hmg/11.9.1069. PMID 11978766.
^ "Entrez Gene: ENAM enamelin".
^ ANTONIO., NANCI, (2012). TEN CATE'S ORAL HISTOLOGY, 8E. [Place of publication not identified],: ELSEVIER INDIA. ISBN 813123343X. OCLC 1027350695.{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)

External links

ENAM human gene location in the UCSC Genome Browser.
ENAM human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132464 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029286 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11978766-5] Mardh CK, Backman B, Holmgren G, Hu JC, Simmer JP, Forsman-Semb K (Apr 2002). "A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)". Hum Mol Genet. 11 (9): 1069–74. doi:10.1093/hmg/11.9.1069. PMID 11978766.

[entrez-6] "Entrez Gene: ENAM enamelin".

[7] ANTONIO., NANCI, (2012). TEN CATE'S ORAL HISTOLOGY, 8E. [Place of publication not identified],: ELSEVIER INDIA. ISBN 813123343X. OCLC 1027350695.{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Enamelin

Structure

Function

Clinical significance

See also

References

Further reading

External links