Clobenpropit: Difference between revisions

Clobenpropit
Clinical data
ATC code	none;
Identifiers
	IUPAC name N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine;
CAS Number	145231-45-4;
PubChem CID	2790;
IUPHAR/BPS	1223;
ChemSpider	2688;
CompTox Dashboard (EPA)	DTXSID3043738 ;
Chemical and physical data
Formula	C14H17ClN4S
Molar mass	308.83 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl;

Content deleted Content added

Inline

Revision as of 16:14, 19 October 2010

Clobenpropit is a histamine H₃ receptor antagonist.^[1] It has neuroprotective effects via stimulation of GABA release in the brain.^[2]

^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". Eur. J. Pharmacol. 567 (3): 206–10. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613

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 '''Clobenpropit''' is a [[histamine]] [[H3 antagonist|H<sub>3</sub> receptor]] [[receptor antagonist|antagonist]].<ref name="pmid17537431">{{cite journal |author=Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P |title=The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes |journal=Eur. J. Pharmacol. |volume=567 |issue=3 |pages=206–10 |year=2007 |pmid=17537431 |doi=10.1016/j.ejphar.2007.04.032}}</ref> It has [[neuroprotective]] effects via stimulation of [[GABA]] release in the brain.<ref>Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. ''European Journal of Pharmacology''. 2007 Jun 1;563(1-3):117-23. PMID 17350613</ref>
-see the link below for the correct structure, please note the substitute is at 4-position, not at 2-position.
-http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2790
 == See also ==