Lidocaine and List of Ed, Edd n Eddy characters: Difference between pages
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This is a description of the twelve recurring [[fictional character]]s from the [[Cartoon Network]] [[animated television series]] '''''[[Ed, Edd n Eddy]]'''''. The show revolves around three main characters (Ed, Edd, and Eddy) and are usually referred to as "the Eds". There is a secondary group of characters (Kevin, Rolf, Nazz, Jimmy, Sarah and Jonny), three neighbor sisters known as "the Kankers", and an absent character (Eddy's brother). |
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| image2 = Lidocaine_spin.gif |
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| IUPAC_name = 2-(diethylamino)-<br />''N''-(2,6-dimethylphenyl)acetamide |
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| ATC_prefix=N01 |
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| ATC_suffix=BB02 |
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| ATC_supplemental={{ATC|C01|BB01}} {{ATC|D04|AB01}} {{ATC|S02|DA01}} {{ATC|C05|AD01}} |
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| PubChem=3676 |
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| DrugBank=APRD00479 |
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| CAS_number = 137-58-6 |
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| C = 14 | H = 22 | N = 2 | O = 1 |
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| molecular_weight = 234.34 g/mol |
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| smiles = CCN(CC)CC(=O)Nc1c(C)cccc1C |
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| melting_point = 68 |
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| bioavailability = 35% (oral) <br /> 3% (topical) |
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| metabolism = [[Liver|Hepatic]], 90% [[CYP1A2]]-mediated |
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| elimination_half-life = 1.5–2 hours |
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| excretion = [[renal]] |
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| pregnancy_AU = A |
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| legal_AU = S4 |
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| legal_US = unregulated |
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| routes_of_administration = [[Intravenous therapy|IV]], [[subcutaneous]], [[topical]] |
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}} |
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'''Lidocaine''' ([[International Nonproprietary Name|INN]]) ({{pronEng|ˈlaɪdoʊkeɪn}}) or '''lignocaine''' (former [[British Approved Name|BAN]]) ({{IPA|/ˈlɪgnoʊkeɪn/}}) is a common [[local anesthetic]] and [[antiarrhythmic agent|antiarrhythmic]] drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, and in minor surgery. |
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== |
== The Eds == |
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[[Image:Eene.JPG|left|thumb|Picture of the main characters, from left to right: Eddy, Edd, and Ed]] |
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Lidocaine, the first [[amino]] [[amide]]-type local anesthetic, was first synthesized under the name xylocaine by [[Nils Löfgren]] in 1943.<ref name="lofgren_1948">{{cite book|author=Nils Löfgren|title=Xylocaine: a new synthetic drug|address=Stockholm|year=1948|note=Inaugural Dissertation May 24th 1948}}</ref> |
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===Ed=== |
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His colleague Bengt Lundqvist made the first injection anesthesia experiments on himself.<ref name="lofgren_1948"/>It was first marketed in [[1948]]. |
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'''Ed''' is the workhorse of the group. He is known to laugh a lot, and he is happy most of the time. His mind is a [[subculture]] grab bag full of comics and monster movies, which he often confuses with reality. Ed is utterly at the mercy of his tyrannical younger sister Sarah, who he cares for deeply, and is an easy target for her manipulations. Much to the dismay of [[germophobic]] Edd, he has poor personal hygiene, even to the point of being terrified of [[soap]]. He loves buttered toast, [[gravy]], [[comics]], [[pudding skin]] and animals, especially chickens. Ed is voiced by [[Matt Hill]]. |
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==Pharmacokinetics== |
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Lidocaine is approximately 90% metabolized in the [[liver]] by [[CYP1A2]] (and to a minor extent [[CYP3A4]]) to the pharmacologically-active [[Metabolomics#metabolites|metabolites]] [[monoethylglycinexylidide]] and [[glycinexylidide]]. |
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=== Edd === |
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The elimination [[half-life]] of lidocaine is approximately 1.5–2 hours in most patients. This may be prolonged in patients with [[liver failure|hepatic impairment]] (average 343 minutes) or [[heart failure|congestive heart failure]] (average 136 minutes). (Thomson ''et al.'', 1973) |
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'''Edd''' is a young inventor and [[Wiktionary:mysophobe|neat freak]]. The most intelligent and good hearted of the trio, he is never seen without his trademark sock-like black [[tuque|ski hat]], hiding some kind of secret unknown to all the kids except Ed and Eddy. To differentiate his [[homophone|homophonic]] name from that of Ed, everyone in the series calls him Double-D. His parents put a heavy [[workload]] on him, communicating an excess of tasks solely through a multitude of [[sticky note]]s. Edd hates being treated terribly by everyone and is easily frustrated. Edd is normally a straight-A student in all of his classes and hates sports (apparently because of an odd, never-discussed "[[dodgeball]]" incident). Edd is an excellent [[pedal steel guitar]] player, although he insists that he detests the instrument. Edd is amazingly intelligent, able to construct complicated machines from [[cardboard]], [[signs]], and various [[junk]] the Eds come across. Edd is voiced by [[Samuel Vincent]]. |
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=== Eddy === |
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==Pharmacodynamics== |
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===Anesthesia=== |
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A greedy, ill-tempered [[con artist]], '''Eddy''' is the self-appointed leader of the Eds. He goes to great lengths to [[scam]] the other kids out of their money, even at the expense of his friends' credibility. His efforts are all in the pursuit of [[Gobstopper|jawbreaker]]s, which he loves as much as he does money. He is very sensitive about his lack of height, suggesting that he may have a [[Napoleon complex]]. Eddy detests school, and more than once has tried to escape. His report card labels him a [[megalomania]]c. Eddy loves his retro styled room, complete with a [[lava lamp]], a large round king-sized bed, a [[disco ball]], and a [[record player|turntable]]. Eddy is mostly seen commanding the two Eds into building the scams while he does non-physical work. He is incredibly selfish, caring for only the well-being of himself and acquiring jawbreakers, even choosing jawbreakers over his friends. Eddy is voiced by [[Tony Sampson]]. |
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Lidocaine alters depolarization in [[neuron]]s, by blocking the fast [[sodium channel|voltage gated sodium (Na<sup>+</sup>) channels]] in the cell membrane<ref name="novartis">{{cite journal |author= Cattterall WA |title= Molecular mechanisms of gating and drug block of sodium channels |journal= Novartis Found Symp |volume=241 |pages=206–32 |year=2002 |pmid=11771647 |doi= 10.1002/0470846682.ch14}}</ref>. With sufficient blockade, the membrane of the presynaptic neuron will not depolarize and so fail to transmit an [[action potential]], leading to its anesthetic effects. |
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Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling. |
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==Other characters== |
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===Indications=== |
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[[Topical]] lidocaine has been shown to relieve [[postherpetic neuralgia]] in some patients, although there is not enough study evidence to recommend it as a [[first-line treatment]]. (Khaliq ''et al.'', 2007) |
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===Jimmy=== |
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[[Intravenous]] or [[intraosseous]] lidocaine is used to blunt the effects of [[laryngoscopy]] during rapid sequence intubation procedures, especially in cases of head injury.{{Fact|date=June 2008}} |
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'''Jimmy''' is a crybaby wuss, who wishes to become famous, and is most often seen spending his time with Sarah. Jimmy is accident-prone, usually sporting many bandages, and is the weakest kid in the cul-de-sac. Though Jimmy has a cowardly and delicate personality, he truly wishes to be strong and muscular. He can be crafty when motivated, and twice has made scams that were very successful, even getting back at the Eds in one utterly cunning scheme. Jimmy has shown how deeply attached he is to Sarah when someone tries to take her away from him. For most of the series he wears a [[Retainer (orthodontic device)|retainer]] to reset his teeth, due to a bowling pin accident during one of Eddy's scams. Jimmy is voiced by [[Keenan Christenson]]. |
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===Contraindications=== |
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Contraindications for the use of lidocaine include: |
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*[[Heart block]], second or third degree (without pacemaker) |
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*Severe [[sinoatrial block]] (without pacemaker) |
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*Serious [[adverse drug reaction]] to lidocaine or amide local anaesthetics |
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*Concurrent treatment with [[quinidine]], [[flecainide]], [[disopyramide]], [[procainamide]] (Class I [[antiarrhythmic agents]]) |
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*Prior use of [[Amiodarone hydrochloride]] |
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*[[Hypotension]] not due to [[Arrhythmia]] |
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*[[Bradycardia]] |
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*[[Accelerated idioventricular rhythm]] |
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===Jonny=== |
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=== Adverse drug reactions === |
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[[Adverse drug reaction]]s (ADRs) are rare when lidocaine is used as a local anesthetic and is administered correctly. Most ADRs associated with lidocaine for anesthesia relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, but [[allergy|allergic]] reactions can rarely occur.{{Fact|date=October 2007}}. |
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[[Image:Jonny2X4 & Plank.JPG|left|thumb|Jonny "2x4" and his imaginary friend, Plank.]] |
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Systemic exposure to excessive quantities of lidocaine mainly result in [[central nervous system]] (CNS) and [[cardiovascular]] effects – CNS effects usually occur at lower [[blood plasma]] concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, [[tinnitus]], tremor, dizziness, blurred vision, [[seizure]]s) followed by depression, and with increasingly heavier exposure: drowsiness, loss of consciousness, [[respiratory depression]] and [[apnoea]]). Cardiovascular effects include [[hypotension]], [[bradycardia]], [[arrhythmia]]s, and/or [[cardiac arrest]] – some of which may be due to [[Hypoxia (medical)|hypoxemia]] secondary to respiratory depression. (Rossi, 2006) |
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'''Jonny ''' (referenced in the credits as "Jonny 2x4") is a loner. A typical [[nuisance]], Jonny has a huge head, and his head repeatedly gets caught in a branch when climbing trees. He talks a lot, and frequently gets on the other kids's nerves. He is rarely seen without his imaginary friend, a board with drawn-on eyes and a mouth, named '''Plank'''. Jonny seems innocent and [[gullible]], and often forgives people no matter what they do. He does not seem to mind the antics of the Eds, and sometimes even enjoys them. He is protective of Plank, and will burst into acts of bravery if Plank is stolen. Jonny is voiced by [[David Paul Grove]]. |
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ADRs associated with the use of intravenous lidocaine are similar to toxic effects from systemic exposure above. These are dose-related and more frequent at high infusion rates (≥3 mg/minute). Common ADRs include: headache, dizziness, drowsiness, confusion, visual disturbances, [[tinnitus]], tremor, and/or [[paraesthesia]]. Infrequent ADRs associated with the use of lidocaine include: [[hypotension]], [[bradycardia]], [[arrhythmia]]s, [[cardiac arrest]], muscle twitching, [[seizure]]s, [[coma]], and/or respiratory depression. (Rossi, 2006) |
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===Kevin=== |
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===Insensitivity to lidocaine=== |
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Relative insensitivity to lidocaine runs in families. In [[hypokalemic sensory overstimulation]], relative insensitivity to lidocaine has been described in people who also have [[attention deficit hyperactivity disorder]]. In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. |
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[[Image:KevinEE'n'E.jpg|thumb|right|150px|'''Kevin''', seen here being heckled by rival Eddy and an off-screen Ed(except for ed's right foot shown next to kevin with a face drawn on the big toe).]] |
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===Dosage forms=== |
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Lidocaine, usually in the form of '''lidocaine hydrochloride''', is available in various forms including: |
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*Injected local anesthetic (sometimes combined with [[epinephrine]]) |
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*Dermal patch (sometimes combined with [[prilocaine]]) |
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*Intravenous injection (sometimes combined with [[epinephrine]]) |
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*Intravenous infusion |
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*Nasal instillation/spray (combined with [[phenylephrine]]) |
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*Oral gel (often referred to as "viscous lidocaine" or abbreviated "lidocaine visc" or "lidocaine hcl visc" in pharmacology; used as teething gel) |
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*Oral liquid |
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*Topical gel (as with [[Aloe Vera]] gels that include Lidocaine) |
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*Topical liquid |
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*Topical patch (Lidocaine 5% patch is marketed as "Lidoderm" in the US (since 1999) and "Versatis" in the UK (since 2007 by Grünenthal)) |
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*Topica. aerosol Spray |
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'''Kevin''' is a [[Jock (athlete)|jock]]. He is cynical and can be cruel at times. Kevin has a garage full of jawbreakers, thanks to his father who works at a jawbreaker factory. He loves customizing his [[bike]], [[skateboards]], and [[snowboards]]. When not riding his trusty bike, he usually hangs out with Rolf and Nazz in the lane. He is a gym assistant and [[hall monitor]] at Peach Creek Junior High and enjoys playing [[American football|football]]. He hates the Eds, especially Eddy, even to the point of [[paranoia]]. He tends to call the Eds "[[dorks]]" and has a habit of coming up with words merged with dork to suit the situation. Kevin is voiced by [[Kathleen Barr]]. |
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==Notes== |
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<references/> |
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== |
===Nazz=== |
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*{{cite journal |author=Khaliq W, Alam S, Puri N |title=Topical lidocaine for the treatment of postherpetic neuralgia |journal=Cochrane Database Syst Rev |volume= |issue=2 |pages=CD004846 |year=2007 |pmid=17443559 |doi=10.1002/14651858.CD004846.pub2 |url=http://www.cochrane.org/reviews/en/ab004846.html}} |
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*Rossi S, editor. [[Australian Medicines Handbook]] 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3 |
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* {{cite journal |author=Thomson PD, Melmon KL, Richardson JA, ''et al'' |title=Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans |journal=Ann. Intern. Med. |volume=78 |issue=4 |pages=499–508 |year=1973 |pmid=4694036 |doi=}} |
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'''Nazz''' is the stereotypical cheerleader/unattainable love interest. [[Trendy]] and attractive, Nazz mostly hangs out with Kevin. All of the boys except Rolf and Jimmy are infatuated with her. Whenever she approaches, the Eds begin to sweat and lose the ability to speak coherently. She is the head [[cheerleader]] at Peach Creek Junior High. Although Nazz is usually depicted as sweet and smart, she can occasionally be a bit eccentric and acts as the stereotypical [[dumb blonde]]. She generally does not mind the Eds unless they bother her. Nazz was voiced by [[Tabitha St. Germain]] in Season 1; [[Jenn Forgie]] in Season 3, and [[Erin Fitzgerald]] in Season 2, and Season 4 to present. |
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{{Antiarrhythmic agents}} |
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{{Vasoprotectives}} |
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===Rolf=== |
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{{Antipruritics}} |
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{{Local anesthetics}} |
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{{Throat preparations}} |
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'''Rolf''' is an immigrant with strange speech and customs. He comes from a curious (presumably Eastern European) culture with odd customs, and has a thick accent to match. He works his parents' small farm within the [[cul-de-sac]], and leads a [[scouting]] group called the "Urban Rangers", which includes Jimmy, Plank, and Jonny. Rolf usually refers to himself in [[third person]], as well as being the son of a [[shepherd]], in which he takes pride. His faithful farm animals are three pigs (one named Wilfred), a goat named Victor, at least six chickens (two named Bridget and Gertrude), a cow named Beatrice, and five sheep. He hardly minds the Eds unless they make a fool out of him or offend him in some way, after which he is not afraid to use brute force. He seems to be very muscular, but this is usually only shown when he is angry. Rolf confuses the rest of the kids to no end with his unusual customs and food-making. Rolf is voiced by [[Peter Kelamis]]. |
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{{Otologicals}} |
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===Sarah=== |
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'''Sarah''' is Ed's bossy [[spoiled]] little sister, who acts cute and charming only when it serves her. Sarah has Ed's unending loyalty and obedience, mostly from her threats of snitching on him. She has a short temper and is easily agitated by others, especially her brother. She is almost always playing with Jimmy, and when she's not, rushes to his aid the moment Jimmy calls her. Sarah writes about her innermost feelings in her diary, and has a slight love for Edd (albeit usually not enough to spare him from her wrath). She is voiced by [[Janyse Jaud]]. |
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===Kanker Sisters=== |
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'''May''', '''Marie''', and '''Lee''' are three sisters who serve as antagonists towards the cul-de-sac and its inhabitants. They live in the nearby [[trailer park]] called Park 'n' Flush. If there is one thing that all of the kids in the cul-de-sac can agree on, it's that they all hate the Kanker Sisters. They are the cul-de-sac's number one enemy and they are feared by all the other kids for their brash, uninhibited demeanor and unpredictable behavior. Lee and Marie are usually slacking off and put May to their chores. While all the Kankers like the Eds, it has been shown that May prefers Ed, Marie for Edd, and Lee for Eddy, respectively. May is voiced by [[Erin Fitzgerald]], except Season 3, when she was voiced by [[Janyse Jaud]]. Marie is voiced by [[Kathleen Barr]]. Lee is voiced by [[Janyse Jaud]]. |
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== Unseen character == |
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=== Eddy's older brother === |
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<!-- Please read the rules listed on the top of the talk page before editing this section. DO NOT add anything about Eddy's brother appearing in the upcoming movie. It is already mentioned on the main page, and has nothing whatsoever to do with his bio.--> |
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Eddy's brother has never appeared on-screen nor has his name been revealed, as he had left the cul-de-sac some time before the start of the series. He can be considered a character because enough of his personality is known. Eddy makes passing references to him when he inspires his ideas, often claiming that his brother was a "whiz" at whatever he happens to be doing. |
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==References== |
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== See also == |
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* [[List of Ed, Edd n Eddy episodes|List of ''Ed, Edd n Eddy'' episodes]] |
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{{Ed, Edd n Eddy}} |
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[[Category:Lists of characters in television animation|Ed, Edd n Eddy]] |
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[[Category:Antiarrhythmic agents]] |
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[[Category: |
[[Category:Ed, Edd n Eddy]] |
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[[Category:Amides]] |
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[[it:Personaggi di Ed, Edd & Eddy]] |
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[[ar:ليدوكائين]] |
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[[cs:Lidokain]] |
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[[da:Lidokain]] |
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[[de:Lidocain]] |
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[[es:Lidocaína]] |
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[[fr:Lidocaïne]] |
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[[hr:Lidokain]] |
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[[it:Lidocaina]] |
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[[he:לידוקאין]] |
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[[hu:Lidokain]] |
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[[nl:Lidocaïne]] |
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[[ja:リドカイン]] |
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[[pl:Lidokaina]] |
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[[pt:Lidocaína]] |
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[[ro:Lidocaină]] |
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[[sr:Лидокаин]] |
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[[fi:Lidokaiini]] |
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[[sv:Lidokain]] |
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[[tr:Lidocaine]] |
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[[ur:Lignocaine]] |
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[[zh:利多卡因]] |
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Revision as of 22:19, 10 October 2008
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This is a description of the twelve recurring fictional characters from the Cartoon Network animated television series Ed, Edd n Eddy. The show revolves around three main characters (Ed, Edd, and Eddy) and are usually referred to as "the Eds". There is a secondary group of characters (Kevin, Rolf, Nazz, Jimmy, Sarah and Jonny), three neighbor sisters known as "the Kankers", and an absent character (Eddy's brother).
The Eds
Ed
Ed is the workhorse of the group. He is known to laugh a lot, and he is happy most of the time. His mind is a subculture grab bag full of comics and monster movies, which he often confuses with reality. Ed is utterly at the mercy of his tyrannical younger sister Sarah, who he cares for deeply, and is an easy target for her manipulations. Much to the dismay of germophobic Edd, he has poor personal hygiene, even to the point of being terrified of soap. He loves buttered toast, gravy, comics, pudding skin and animals, especially chickens. Ed is voiced by Matt Hill.
Edd
Edd is a young inventor and neat freak. The most intelligent and good hearted of the trio, he is never seen without his trademark sock-like black ski hat, hiding some kind of secret unknown to all the kids except Ed and Eddy. To differentiate his homophonic name from that of Ed, everyone in the series calls him Double-D. His parents put a heavy workload on him, communicating an excess of tasks solely through a multitude of sticky notes. Edd hates being treated terribly by everyone and is easily frustrated. Edd is normally a straight-A student in all of his classes and hates sports (apparently because of an odd, never-discussed "dodgeball" incident). Edd is an excellent pedal steel guitar player, although he insists that he detests the instrument. Edd is amazingly intelligent, able to construct complicated machines from cardboard, signs, and various junk the Eds come across. Edd is voiced by Samuel Vincent.
Eddy
A greedy, ill-tempered con artist, Eddy is the self-appointed leader of the Eds. He goes to great lengths to scam the other kids out of their money, even at the expense of his friends' credibility. His efforts are all in the pursuit of jawbreakers, which he loves as much as he does money. He is very sensitive about his lack of height, suggesting that he may have a Napoleon complex. Eddy detests school, and more than once has tried to escape. His report card labels him a megalomaniac. Eddy loves his retro styled room, complete with a lava lamp, a large round king-sized bed, a disco ball, and a turntable. Eddy is mostly seen commanding the two Eds into building the scams while he does non-physical work. He is incredibly selfish, caring for only the well-being of himself and acquiring jawbreakers, even choosing jawbreakers over his friends. Eddy is voiced by Tony Sampson.
Other characters
Jimmy
Jimmy is a crybaby wuss, who wishes to become famous, and is most often seen spending his time with Sarah. Jimmy is accident-prone, usually sporting many bandages, and is the weakest kid in the cul-de-sac. Though Jimmy has a cowardly and delicate personality, he truly wishes to be strong and muscular. He can be crafty when motivated, and twice has made scams that were very successful, even getting back at the Eds in one utterly cunning scheme. Jimmy has shown how deeply attached he is to Sarah when someone tries to take her away from him. For most of the series he wears a retainer to reset his teeth, due to a bowling pin accident during one of Eddy's scams. Jimmy is voiced by Keenan Christenson.
Jonny
Jonny (referenced in the credits as "Jonny 2x4") is a loner. A typical nuisance, Jonny has a huge head, and his head repeatedly gets caught in a branch when climbing trees. He talks a lot, and frequently gets on the other kids's nerves. He is rarely seen without his imaginary friend, a board with drawn-on eyes and a mouth, named Plank. Jonny seems innocent and gullible, and often forgives people no matter what they do. He does not seem to mind the antics of the Eds, and sometimes even enjoys them. He is protective of Plank, and will burst into acts of bravery if Plank is stolen. Jonny is voiced by David Paul Grove.
Kevin
Kevin is a jock. He is cynical and can be cruel at times. Kevin has a garage full of jawbreakers, thanks to his father who works at a jawbreaker factory. He loves customizing his bike, skateboards, and snowboards. When not riding his trusty bike, he usually hangs out with Rolf and Nazz in the lane. He is a gym assistant and hall monitor at Peach Creek Junior High and enjoys playing football. He hates the Eds, especially Eddy, even to the point of paranoia. He tends to call the Eds "dorks" and has a habit of coming up with words merged with dork to suit the situation. Kevin is voiced by Kathleen Barr.
Nazz
Nazz is the stereotypical cheerleader/unattainable love interest. Trendy and attractive, Nazz mostly hangs out with Kevin. All of the boys except Rolf and Jimmy are infatuated with her. Whenever she approaches, the Eds begin to sweat and lose the ability to speak coherently. She is the head cheerleader at Peach Creek Junior High. Although Nazz is usually depicted as sweet and smart, she can occasionally be a bit eccentric and acts as the stereotypical dumb blonde. She generally does not mind the Eds unless they bother her. Nazz was voiced by Tabitha St. Germain in Season 1; Jenn Forgie in Season 3, and Erin Fitzgerald in Season 2, and Season 4 to present.
Rolf
Rolf is an immigrant with strange speech and customs. He comes from a curious (presumably Eastern European) culture with odd customs, and has a thick accent to match. He works his parents' small farm within the cul-de-sac, and leads a scouting group called the "Urban Rangers", which includes Jimmy, Plank, and Jonny. Rolf usually refers to himself in third person, as well as being the son of a shepherd, in which he takes pride. His faithful farm animals are three pigs (one named Wilfred), a goat named Victor, at least six chickens (two named Bridget and Gertrude), a cow named Beatrice, and five sheep. He hardly minds the Eds unless they make a fool out of him or offend him in some way, after which he is not afraid to use brute force. He seems to be very muscular, but this is usually only shown when he is angry. Rolf confuses the rest of the kids to no end with his unusual customs and food-making. Rolf is voiced by Peter Kelamis.
Sarah
Sarah is Ed's bossy spoiled little sister, who acts cute and charming only when it serves her. Sarah has Ed's unending loyalty and obedience, mostly from her threats of snitching on him. She has a short temper and is easily agitated by others, especially her brother. She is almost always playing with Jimmy, and when she's not, rushes to his aid the moment Jimmy calls her. Sarah writes about her innermost feelings in her diary, and has a slight love for Edd (albeit usually not enough to spare him from her wrath). She is voiced by Janyse Jaud.
Kanker Sisters
May, Marie, and Lee are three sisters who serve as antagonists towards the cul-de-sac and its inhabitants. They live in the nearby trailer park called Park 'n' Flush. If there is one thing that all of the kids in the cul-de-sac can agree on, it's that they all hate the Kanker Sisters. They are the cul-de-sac's number one enemy and they are feared by all the other kids for their brash, uninhibited demeanor and unpredictable behavior. Lee and Marie are usually slacking off and put May to their chores. While all the Kankers like the Eds, it has been shown that May prefers Ed, Marie for Edd, and Lee for Eddy, respectively. May is voiced by Erin Fitzgerald, except Season 3, when she was voiced by Janyse Jaud. Marie is voiced by Kathleen Barr. Lee is voiced by Janyse Jaud.
Unseen character
Eddy's older brother
Eddy's brother has never appeared on-screen nor has his name been revealed, as he had left the cul-de-sac some time before the start of the series. He can be considered a character because enough of his personality is known. Eddy makes passing references to him when he inspires his ideas, often claiming that his brother was a "whiz" at whatever he happens to be doing.
