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Protein-coding gene in the species Homo sapiens
Polypeptide N-acetylgalactosaminyltransferase 3 is an enzyme that in humans is encoded by the GALNT3 gene .[5] [6] [7]
This gene encodes UDP-GalNAc transferase 3, a member of the polypeptide GalNAc transferase (GalNAc-T) family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O -linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O -glycosylationhomologous to other family members; however, the enzymes have different substrate specificities.[7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000115339 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026994 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bennett EP, Weghuis DO, Merkx G, van Kessel AG, Eiberg H, Clausen H (Jul 1998). "Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family" . Glycobiology . 8 (6): 547–55. doi :10.1093/glycob/8.6.547 PMID 9592121 . ^ Topaz O, Shurman DL, Bergman R, Indelman M, Ratajczak P, Mizrachi M, Khamaysi Z, Behar D, Petronius D, Friedman V, Zelikovic I, Raimer S, Metzker A, Richard G, Sprecher E (May 2004). "Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis" . Nat Genet . 36 (6): 579–81. doi :10.1038/ng1358 PMID 15133511 . ^ a b "Entrez Gene: GALNT3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)" .
Further reading [ edit ]
Bennett EP, Hassan H, Clausen H (1996). "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3" . J. Biol. Chem . 271 (29): 17006–12. doi :10.1074/jbc.271.29.17006 PMID 8663203 . Wandall HH, Hassan H, Mirgorodskaya E, et al. (1997). "Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3" . J. Biol. Chem . 272 (38): 23503–14. doi :10.1074/jbc.272.38.23503 PMID 9295285 . Röttger S, White J, Wandall HH, et al. (1998). "Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus". J. Cell Sci . 111 (1): 45–60. doi :10.1242/jcs.111.1.45 . PMID 9394011 . Mandel U, Hassan H, Therkildsen MH, et al. (1999). "Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family" . Glycobiology . 9 (1): 43–52. doi :10.1093/glycob/9.1.43 PMID 9884405 . Dosaka-Akita H, Kinoshita I, Yamazaki K, et al. (2002). "N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers" . Br. J. Cancer . 87 (7): 751–5. doi :10.1038/sj.bjc.6600536 . PMC 2364253 PMID 12232759 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Argüeso P, Tisdale A, Mandel U, et al. (2003). "The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization" . Invest. Ophthalmol. Vis. Sci . 44 (1): 86–92. doi :10.1167/iovs.02-0181 PMID 12506059 . Onitsuka K, Shibao K, Nakayama Y, et al. (2003). "Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma" . Cancer Sci . 94 (1): 32–6. doi :10.1111/j.1349-7006.2003.tb01348.x PMID 12708471 . S2CID 42340701 . Yamamoto S, Nakamori S, Tsujie M, et al. (2004). "Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas". Pathobiology . 71 (1): 12–8. doi :10.1159/000072957 . PMID 14555840 . S2CID 20321446 . Gu C, Oyama T, Osaki T, et al. (2004). "Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence" . Br. J. Cancer . 90 (2): 436–42. doi :10.1038/sj.bjc.6601531 . PMC 2409559 PMID 14735190 . Miyahara N, Shoda J, Kawamoto T, et al. (2004). "Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder" . Clin. Cancer Res . 10 (6): 2090–9. doi :10.1158/1078-0432.CCR-1024-03 PMID 15041730 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ishikawa M, Kitayama J, Kohno K, Nagawa H (2005). "The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus". Pathobiology . 72 (3): 139–45. doi :10.1159/000084117 . PMID 15860931 . S2CID 33360750 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Kato K, Jeanneau C, Tarp MA, et al. (2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation" . J. Biol. Chem . 281 (27): 18370–7. doi :10.1074/jbc.M602469200 PMID 16638743 . Ichikawa S, Imel EA, Sorenson AH, et al. (2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene" . J. Clin. Endocrinol. Metab . 91 (11): 4472–5. doi :10.1210/jc.2006-1247 PMID 16940445 . Barbieri AM, Filopanti M, Bua G, Beck-Peccoz P (2007). "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis" . J. Hum. Genet . 52 (5): 464–8. doi :10.1007/s10038-007-0126-5 PMID 17351710 . Inoue T, Eguchi T, Oda Y, et al. (2007). "Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-" . Mod. Pathol . 20 (2): 267–76. doi :10.1038/modpathol.3800700 PMID 17361208 .
