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{{Short description|Protein-coding gene in the species Homo sapiens}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nidogen-2''', also known as '''osteonidogen''', is a [[basal lamina]] [[protein]] of the [[nidogen]] family. It was the second nidogen to be described after [[nidogen-1]] (entactin). Both play key roles during late [[embryonic development]].<ref>{{cite journal | vauthors = Miosge N, Holzhausen S, Zelent C, Sprysch P, Herken R | title = Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development | journal = The Histochemical Journal | volume = 33 | issue = 9–10 | pages = 523–30 | year = 2002 | pmid = 12005023 | doi = 10.1023/A:1014995523521 | s2cid = 818451 }}</ref> In humans it is encoded by the ''NID2'' [[gene]].<ref name="pmid9733643">{{cite journal | vauthors = Kohfeldt E, Sasaki T, Göhring W, Timpl R | title = Nidogen-2: a new basement membrane protein with diverse binding properties | journal = Journal of Molecular Biology | volume = 282 | issue = 1 | pages = 99–109 | date = Sep 1998 | pmid = 9733643 | doi = 10.1006/jmbi.1998.2004 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NID2 nidogen 2 (osteonidogen)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22795}}</ref>
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


== References ==
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{reflist|2}}
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nidogen 2 (osteonidogen)
| HGNCid = 13389
| Symbol = NID2
| AltSymbols =;
| OMIM = 605399
| ECnumber =
| Homologene = 40575
| MGIid = 1298229
| GeneAtlas_image1 = PBB_GE_NID2_204114_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005518 |text = collagen binding}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0008218 |text = bioluminescence}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 22795
| Hs_Ensembl = ENSG00000087303
| Hs_RefseqProtein = NP_031387
| Hs_RefseqmRNA = NM_007361
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 51541271
| Hs_GenLoc_end = 51605696
| Hs_Uniprot = Q14112
| Mm_EntrezGene = 18074
| Mm_Ensembl = ENSMUSG00000021806
| Mm_RefseqmRNA = NM_008695
| Mm_RefseqProtein = NP_032721
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 18541980
| Mm_GenLoc_end = 18601770
| Mm_Uniprot = Q3TPN0
}}
}}
'''Nidogen 2 (osteonidogen)''', also known as '''NID2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NID2 nidogen 2 (osteonidogen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22795| accessdate = }}</ref>


== Further reading ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Basement membranes, which are composed of type IV collagens (see MIM 120130), laminins (see LAMC1; MIM 150290), perlecan (HSPG2; MIM 142461), and nidogen (see NID1; MIM 131390), are thin pericellular protein matrices that control a large number of cellular activities, including adhesion, migration, differentiation, gene expression, and apoptosis.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NID2 nidogen 2 (osteonidogen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22795| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Ulazzi L, Sabbioni S, Miotto E, Veronese A, Angusti A, Gafà R, Manfredini S, Farinati F, Sasaki T, Lanza G, Negrini M | title = Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer | journal = Molecular Cancer | volume = 6 | issue = 1 | pages = 17 | year = 2007 | pmid = 17328794 | pmc = 1831485 | doi = 10.1186/1476-4598-6-17 | doi-access = free }}
{{PBB_Further_reading
* {{cite journal | vauthors = Nischt R, Schmidt C, Mirancea N, Baranowsky A, Mokkapati S, Smyth N, Woenne EC, Stark HJ, Boukamp P, Breitkreutz D | title = Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture | journal = The Journal of Investigative Dermatology | volume = 127 | issue = 3 | pages = 545–54 | date = Mar 2007 | pmid = 17008882 | doi = 10.1038/sj.jid.5700562 | doi-access = free }}
| citations =
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
*{{cite journal | author=Ulazzi L, Sabbioni S, Miotto E, ''et al.'' |title=Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. |journal=Mol. Cancer |volume=6 |issue= |pages= 17 |year= 2007 |pmid= 17328794 |doi= 10.1186/1476-4598-6-17 }}
*{{cite journal | author=Nischt R, Schmidt C, Mirancea N, ''et al.'' |title=Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture. |journal=J. Invest. Dermatol. |volume=127 |issue= 3 |pages= 545-54 |year= 2007 |pmid= 17008882 |doi= 10.1038/sj.jid.5700562 }}
* {{cite journal | vauthors = Miosge N, Sasaki T, Timpl R | title = Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice | journal = Matrix Biology | volume = 21 | issue = 7 | pages = 611–21 | date = Nov 2002 | pmid = 12475645 | doi = 10.1016/S0945-053X(02)00070-7 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Tu H, Sasaki T, Snellman A, Göhring W, Pirilä P, Timpl R, Pihlajaniemi T | title = The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin | journal = The Journal of Biological Chemistry | volume = 277 | issue = 25 | pages = 23092–9 | date = Jun 2002 | pmid = 11956183 | doi = 10.1074/jbc.M107583200 | doi-access = free }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R | title = Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins | journal = Journal of Molecular Biology | volume = 314 | issue = 4 | pages = 751–63 | date = Dec 2001 | pmid = 11733994 | doi = 10.1006/jmbi.2001.5176 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Sasaki T, Göhring W, Miosge N, Abrams WR, Rosenbloom J, Timpl R | title = Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins | journal = FEBS Letters | volume = 460 | issue = 2 | pages = 280–4 | date = Oct 1999 | pmid = 10544250 | doi = 10.1016/S0014-5793(99)01362-9 | s2cid = 25139630 | doi-access = }}
*{{cite journal | author=Miosge N, Sasaki T, Timpl R |title=Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice. |journal=Matrix Biol. |volume=21 |issue= 7 |pages= 611-21 |year= 2003 |pmid= 12475645 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
*{{cite journal | author=Miosge N, Holzhausen S, Zelent C, ''et al.'' |title=Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development. |journal=Histochem. J. |volume=33 |issue= 9-10 |pages= 523-30 |year= 2002 |pmid= 12005023 |doi= }}
*{{cite journal | author=Tu H, Sasaki T, Snellman A, ''et al.'' |title=The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23092-9 |year= 2002 |pmid= 11956183 |doi= 10.1074/jbc.M107583200 }}
*{{cite journal | author=Sasaki T, Göhring W, Mann K, ''et al.'' |title=Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins. |journal=J. Mol. Biol. |volume=314 |issue= 4 |pages= 751-63 |year= 2002 |pmid= 11733994 |doi= 10.1006/jmbi.2001.5176 }}
*{{cite journal | author=Sasaki T, Göhring W, Miosge N, ''et al.'' |title=Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins. |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 280-4 |year= 1999 |pmid= 10544250 |doi= }}
*{{cite journal | author=Kohfeldt E, Sasaki T, Göhring W, Timpl R |title=Nidogen-2: a new basement membrane protein with diverse binding properties. |journal=J. Mol. Biol. |volume=282 |issue= 1 |pages= 99-109 |year= 1998 |pmid= 9733643 |doi= 10.1006/jmbi.1998.2004 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
}}
{{refend}}
{{refend}}


[[Category:Extracellular matrix proteins]]
{{gene-14-stub}}
[[Category:Genes on human chromosome 14]]

Latest revision as of 00:08, 3 December 2023

NID2
Identifiers
AliasesNID2, NID-2, nidogen 2
External IDsOMIM: 605399 MGI: 1298229 HomoloGene: 40575 GeneCards: NID2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007361

NM_008695

RefSeq (protein)

NP_031387

NP_032721

Location (UCSC)Chr 14: 52 – 52.07 MbChr 14: 19.8 – 19.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nidogen-2, also known as osteonidogen, is a basal lamina protein of the nidogen family. It was the second nidogen to be described after nidogen-1 (entactin). Both play key roles during late embryonic development.[5] In humans it is encoded by the NID2 gene.[6][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087303Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021806Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miosge N, Holzhausen S, Zelent C, Sprysch P, Herken R (2002). "Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development". The Histochemical Journal. 33 (9–10): 523–30. doi:10.1023/A:1014995523521. PMID 12005023. S2CID 818451.
  6. ^ Kohfeldt E, Sasaki T, Göhring W, Timpl R (Sep 1998). "Nidogen-2: a new basement membrane protein with diverse binding properties". Journal of Molecular Biology. 282 (1): 99–109. doi:10.1006/jmbi.1998.2004. PMID 9733643.
  7. ^ "Entrez Gene: NID2 nidogen 2 (osteonidogen)".

Further reading[edit]