A-endopsychosin

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α-Endopsychosin ( CAS number 99638-41-2) is a hypothetical antagonist of the binding site for phencyclidine on the NMDA receptor .

properties

α-Endopsychosin was first suspected in extracts from porcine brains and is probably also endogenous in humans. It's probably a peptide . It has been suggested that, like β-endopsychosin, it binds to the sigma receptor and is involved in the sensation of near-death experiences .

literature

  • DA DiMaggio, PC Contreras, R. Quirion, TL O'Donohue: Isolation and identification of an endogenous ligand for the phencyclidine receptor. In: NIDA research monograph. Volume 64, 1986, pp. 24-36, PMID 3012346 .

Individual evidence

  1. ↑ a b Contreras PC, DiMaggio DA, O'Donohue TL: Evidence for an endogenous peptide ligand and antagonist for PCP receptors . In: Prog. Clin. Biol. Res . 192, 1985, pp. 495-498. PMID 3001770 .
  2. ^ John Calvin M. Breast: Neurological Aspects of Substance Abuse . Butterworth-Heinemann, 2004, ISBN 978-0-7506-7313-6 , p. 296.
  3. ^ A b Allan Tasman, Stephen M. Goldfinger: American Psychiatric Press Review of Psychiatry . American Psychiatric Pub, 1991, ISBN 978-0-88048-436-7 , p. 494.
  4. ^ Jansen KL: Neuroscience and the near-death experience: roles for the NMSA-PCP receptor, the sigma receptor and the endopsychosins . In: Med. Hypotheses . 31, No. 1, January 1990, pp. 25-29. PMID 2156135 .