Adverse outcome pathway

The concept of Adverse Outcome Pathways (AOP) allows the connection of biological processes and adverse effects, which has found its way into the risk assessment .

In addition to the mode of action , AOP also includes the upstream exposure and the downstream effects at the level of the individual organism.

The use of AOP in risk assessment allows the inclusion of mechanistic toxicological data to be expanded. The European chemicals regulation REACH does not yet take AOP into account.

literature

N. Burden, F. Sewell, ME Andersen, A. Boobis, JK Chipman, MT Cronin, TH Hutchinson, I. Kimber, M. Whelan: Adverse Outcome Pathways can drive non-animal approaches for safety assessment. Journal of Applied Toxicology . 2015, DOI: 10.1002 / jat.3165 , PMID 25943792 .

Web links

Individual evidence

^ Committee on Toxicity Testing and Assessment of Environmental Agents, Board on Environmental Studies and Toxicology [...], National Research Council of the National Academies: Toxicity testing in the 21st century: a vision and a strategy . The National Academic Press, Washington 2007, ISBN 978-0-309-15173-3 .
↑ ^a ^b Gerald T. Ankley et al .: Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment . In: Environmental Toxicology and Chemistry . 29, No. 3, 2010, pp. 730-741. doi : 10.1002 / etc.34 . PMID 20821501 .
↑ OECD : What is the Adverse Outcome Pathway (AOP) concept? , Slide 3
↑ Vincent J. Kramer et al .: Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects . In: Environmental Toxicology and Chemistry . 30, No. 1, 2011, pp. 64-76. doi : 10.1002 / etc.375 . PMID 20963853 .
↑ Mark Cronin, Judith Madden: In silico toxicology principles and applications . Royal Society of Chemistry , Cambridge 2010, ISBN 978-1-84973-209-3 .

[1] Committee on Toxicity Testing and Assessment of Environmental Agents, Board on Environmental Studies and Toxicology [...], National Research Council of the National Academies: Toxicity testing in the 21st century: a vision and a strategy . The National Academic Press, Washington 2007, ISBN 978-0-309-15173-3 .

[Ankley_2010-2] Gerald T. Ankley et al .: Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment . In: Environmental Toxicology and Chemistry . 29, No. 3, 2010, pp. 730-741. doi : 10.1002 / etc.34 . PMID 20821501 .

[3] OECD : What is the Adverse Outcome Pathway (AOP) concept? , Slide 3

[4] Vincent J. Kramer et al .: Adverse outcome pathways and ecological risk assessment: Bridging to population-level effects . In: Environmental Toxicology and Chemistry . 30, No. 1, 2011, pp. 64-76. doi : 10.1002 / etc.375 . PMID 20963853 .

[5] Mark Cronin, Judith Madden: In silico toxicology principles and applications . Royal Society of Chemistry , Cambridge 2010, ISBN 978-1-84973-209-3 .