Cupid routine

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Amorfrutins are a class of naturally occurring organic compounds that was first described in 1981. They belong to the group of secondary plant substances and were first discovered in the bastard indigo ( Amorpha fruticosa ), as well as in the legume plant family , namely the liquorice root .

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The Amorfrutins belong to the group of hydroxybenzoic acids with additional alkoxy and alkenyl substituents .

Cupid routine
Amorfrutines.svg
General structure of the cupid routine
structure Amorfrutin A.svg Amorfrutin B.svg Amorfrutin 2.svg
designation Amorfrutin A Amorfrutin B Amorfrutin 2
IUPAC designation 2-Hydroxy-4-methoxy-3- (3-methyl-2-buten-1-yl) -6- (2-phenylethyl) benzoic acid 3- (3,7-Dimethyl-2,6-octadien-1-yl) -2-hydroxy-4-methoxy-6- (2-phenylethyl) benzoic acid 2-Hydroxy-4-methoxy-3- (3-methyl-2-buten-1-yl) -6-pentylbenzoic acid
CAS number 80489-90-3 - -
PubChem 17950432 24739090 23874497
Molecular formula C 21 H 24 O 4 C 26 H 32 O 4 C 18 H 26 O 4
Molar mass 340.4 g mol −1 408.5 g mol −1 306.4 g mol −1

properties

According to a study in animal models, the amorfrutins of licorice root lower blood sugar by increasing insulin sensitivity and have an anti-inflammatory effect. It is assumed that the antidiabetic effect is achieved by activating the PPAR -gamma receptor (peroxisome proliferator activated receptor). In animal experiments, Amorfrutins were also very well tolerated and not harmful to the liver.

Individual evidence

  1. ^ Lester A. Mitscher, Young Han Park, Ali Alshamma, P.Bryan Hudson, Thomas Haas: Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa . In: Phytochemistry . tape 20 , no. January 4 , 1981, pp. 781 , doi : 10.1016 / 0031-9422 (81) 85174-6 .
  2. ↑ Sascha Sauer: Amorfrutins: A Promising Class of Natural Products Are Beneficial to Health did . In: ChemBioChem . tape 15 , no. 9 , June 16, 2014, p. 1231-1238 , doi : 10.1002 / cbic.201402124 .
  3. ↑ C. Weidner, JC de Groot, A. Prasad, A. Freiwald, C. Quedenau, M. Kliem, A. Witzke, V. Kodelja, C.-T. Han, S. Giegold, M. Baumann, B. Klebl, K. Siems, L. Muller-Kuhrt, A. Schurmann, R. Schuler, AFH Pfeiffer, FC Schroeder, K. Bussow, S. Sauer: Amorfrutins are potent antidiabetic dietary natural products . In: Proceedings of the National Academy of Sciences . tape 109 , no. 19 , May 8, 2012, p. 7257-7262 , doi : 10.1073 / pnas.1116971109 .
  4. ↑ Ulrike Viegener: Amorfrutine - licorice against diabetes. In: Pharmaceutical newspaper. Avoxa - Mediengruppe Deutscher Apotheker GmbH, April 24, 2012, accessed on August 7, 2017 .