Amphipathic helix

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An amphipathic helix is an α-helix whose hydrophobic and polar amino acid side chains are on opposite sides, so that a lipophilic and a hydrophilic surface can develop. Amphipathic helices occur, for example, as anchoring of membrane proteins , where part of a protein is often located in the lipid membrane and part in the aqueous cytosol . They also represent an important part of the activation domain of many transcription factors , and thus enable contact between the corresponding transcription factors and other elements of transcription .

Individual evidence

  1. ↑ Manuel Giménez-Andrés, Alenka Čopič, Bruno Antonny: The Many Faces of Amphipathic Helices . In: Biomolecules . 8, No. 3, 2018, ISSN  2218-273X , p. 45. doi : 10.3390 / biom8030045 .
  2. ↑ Guillaume Drin, Bruno Antonny: Amphipathic helices and membrane curvature . In: FEBS Letters . 584, No. 9, 2010, ISSN  0014-5793 , pp. 1840-1847. doi : 10.1016 / j.febslet.2009.10.022 .
  3. ↑ amphipathic helix. Retrieved February 18, 2020 .