Amyloid polyneuropathy

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Classification according to ICD-10
E85 Amyloid polyneuropathy
ICD-10 online (WHO version 2019)

The amyloid polyneuropathy is a systemic, peripheral polyneuropathy , which both the sensorimotor and the autonomic nervous system is concerned, due to deposition in the tissue ( amyloidosis ).

A distinction must be made between acquired and familial ( innate ) forms.

Acquired amyloid polyneuropathies

The following subdivision is used here:

  • AL amyloidosis
    • Localized form , synonyms: amyloidosis, localized primary; AL amyloidosis, localized; Immunoglobulin amyloidosis, localized
    • Systemic form , synonyms: multiple myeloma ; Amyloidosis, primary systemic; AL amyloidosis, systemic

Familial amyloid polyneuropathies

This group, abbreviated as FAP, is divided into:

  • FAP I , synonyms: Wohlwill-Andrade's syndrome, familial amyloid polyneuropathy type I , mutation in the transthyretin - Gen
  • FAP II , synonyms: Rukavina syndrome, Indiana type , also related to transthyretin
  • FAP III , synonyms: van Allen syndrome, Iowa type , apolipoprotein A1 deficiency
  • FAP IV , synonyms: Meretoja syndrome, Finnish-type; Agel amyloidosis; Amyloidosis, familial, Finnish type; Amyloidosis, hereditary, Finnish type; Amyloid polyneuropathy, familial, type 4; Gelsolin amyloidosis , related to gelsolin, s. Latticed corneal dystrophy

Individual evidence

  1. ↑ Acquired amyloid polyneuropathy. In: Orphanet (Rare Disease Database).
  2. ↑ AL amyloidosis. In: Orphanet (Rare Disease Database).
  3. ↑ amyloidosis, localized primary. In: Orphanet (Rare Disease Database).
  4. ↑ amyloidosis, primary systemic. In: Orphanet (Rare Disease Database).
  5. ↑ Bernfried Leiber (founder): The clinical syndromes. Syndromes, sequences and symptom complexes . Ed .: G. Burg, J. Kunze, D. Pongratz, PG Scheurlen, A. Schinzel, J. Spranger. 7., completely reworked. Edition. tape 2 : symptoms . Urban & Schwarzenberg, Munich et al. 1990, ISBN 3-541-01727-9 .
  6. ↑ M. Mahloudji, RD Teasdall, JJ Adamkiewicz, WH Hartmann, PA Lambird, VA McKusick: The genetic amyloidoses with particular reference to hereditary neuropathic amyloidosis, type II (Indiana or Rukavina type). In: Medicine. Volume 48, Number 1, January 1969, pp. 1-37, PMID 4884226 (review).
  7. ^ Agel amyloidosis. In: Orphanet (Rare Disease Database).