Attack time

Under the stop time (engl. Onset time ) of a drug refers to the time from administration of the drug up to the (maximum) effect.

The concept of attack time summarizes the first three pharmacokinetic stages of the release, absorption and distribution of a substance or a drug under the clinical aspect of administration (usually injection) up to the manifest effect. This makes it easier to compare different substances with one another. Most of the time, we are talking about substances that are injected, so the levels of release and absorption are not relevant.

The attack time is therefore dependent on the distribution in the body tissues, which is determined by the degree of fat or water solubility of the substance, but also the charge or the ability to cross the blood-brain barrier . But it is z. B. with muscle relaxants also depends on the amount administered. The desired shortening of the attack time of rocuronium is based on the lower effect of the individual molecule with the need to administer a larger number of molecules compared to other muscle relaxants.

In addition, the term attack time is often used for local anesthetics .

Individual evidence

1. ^ Norbert Roewer, Holger Thiel: Taschenatlas der Anästhesie Georg Thieme Verlag 2010, p. 60
2. ↑ F. Latorre, A. Stanek, HW Gervais, PP Kleemann: Intubation conditions according to Rocuronium and Succinylcholine . In: Anästhesiol Intensivmed Emergency Med Schmerzther . 31 (8), 1996, pp. 470-473.
3. ↑ Overview of the attack times of local anesthetics in Hans Walter Striebel: Anesthesia, Intensive Care Medicine, Emergency Medicine for Studies and Training Schattauer Verlag 2009, p. 156

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