Antistreptolysin O

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Antibodies against streptolysin O are designated as antistreptolysin O , or ASLO , ASO or ASL for short .

After infection with β-hemolytic streptococci , antibodies against streptolysin O are formed. The concentration of these antibodies is indicated by the ASLO titer , also known as the antistreptolysin titer . The reference range is 0 to 200 IU / ml. Elevated values ​​can be detected one to three weeks after infection, the peak after three to six weeks. Elevated values ​​indicate that streptococcal infection has been overcome. After a properly treated streptococcal infection, this value should slowly decrease. If this is not the case, then after chronic inflammation foci (also called focus) of the tonsils, teeth, paranasal sinuses etc. a. to search.

A negative result does not rule out a streptococcal infection (especially of the skin). A slight to moderate increase could also be caused by an infection that was long ago. In the case of infections long ago, the ASLO level changes only slightly.

Streptolysin O can cause reactions in the inner lining of the heart ( endocarditis or heart valve inflammation), kidney inflammation ( glomerulonephritis ) or in the joints (rheumatic reactions).

According to a study on 87 healthy subjects, the level of the antistreptolysin titer (AST) does not correlate with the level of the hsCRP (as a parameter for the inflammatory activity) in healthy subjects. The prevalence of asymptomatic carriers of group A streptococci ("GAS") varies considerably in the literature and is between 6% and 40%. A control of the AST after a GAS-positive tonsillitis is not useful to assess the success of the therapy.

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Individual evidence

  1. ↑ A. Nava, G. Robles, Mendoza et al: Correlation between serum levels of antistreptolysin O and C reactive protein. Revista Alergia México. 54, 2007, pp. 201-204. (on-line)
  2. ^ Servizio sanitario regional Emilia-Romagna. Faringotonsillite in etá pediatrica; Linea guida regional. Bologna, ITA: Servizio sanitario regional; July 2007 (online)