Autoimmune / Inflammatory Syndrome Induced by Adjuvants

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Under the autoimmune / inflammatory syndrome induced by adjuvants (English: autoimmune / inflammatory syndrome induced by adjuvants , short: ASIA ) various autoimmune diseases are summarized. ASIA was postulated in 2011 by the Israeli immunologist Yehuda Shoenfeld .

background

According Shoenfelds hypothesis, the syndrome is intended to include, inter alia, the following diseases: autoimmune diseases , sick building syndrome , Macrophagic Myofasciitis , Gulf War Syndrome , Silikonose and generally such symptoms after vaccination (especially HPV vaccine may occur). Shoenfeld also considers Sjogren's Syndrome to be part of ASIA. ASIA is said to be triggered by chronic exposure to silicone , but also substances such as tetramethylpentadecane , aluminum- containing adjuvants or adjuvants contained in vaccinations, and infectious components. ASIA could manifest itself within days, but also after 23 years.

reception

ASIA represents a previously hypothetical concept, as the phenomenon could neither be reproducibly proven in studies nor a causal relationship confirmed after vaccinations. For example, a study carried out on over 18,000 patients did not reveal any evidence for the existence of ASIA. Patients who received specific immunotherapy with allergens containing aluminum even had fewer autoimmune diseases than the comparison group with (aluminum-free) conventional treatment.

It is also criticized that the syndrome is far too broad and can in fact affect the whole population. Animal studies are also methodologically flawed, and several ASIA-supporting studies have been withdrawn due to quality deficiencies.

According to the assessment of medical societies, the WHO , the EMA and others , the fact that autoimmune diseases are caused by vaccinations, especially HPV vaccines, is considered refuted. In general, all studies on the incidence of autoimmune diseases in vaccinated versus unvaccinated populations have not shown an increased risk of such diseases in connection with vaccinations.

Web links

Individual evidence

  1. ^ Yehuda Shoenfeld and Nancy Agmon-Levin: 'ASIA' - autoimmune / inflammatory syndrome induced by adjuvants . In: Journal of Autoimmunity . tape 36 , no. 1 , February 2011, p. 4–8 , doi : 10.1016 / j.jaut.2010.07.003 , PMID 20708902 .
  2. ↑ Luis J. Jara et al .: Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld's syndrome) . In: Immunologic Research . tape 65 , no. 1 , February 2017, p. 8-16 , doi : 10.1007 / s12026-016-8811-0 , PMID 27412294 .
  3. ^ A b Carlo Perricone et al .: Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects . In: Journal of Autoimmunity . tape 47 , December 1, 2013, p. 1–16 , doi : 10.1016 / j.jaut.2013.10.004 .
  4. ↑ a b c Rohan Ameratunga et al .: Evidence Refuting the Existence of Autoimmune / Autoinflammatory Syndrome Induced by Adjuvants (ASIA) . In: The Journal of Allergy and Clinical Immunology: In Practice . tape 5 , no. 6 , November 1, 2017, p. 1551–1555.e1 , doi : 10.1016 / j.jaip.2017.06.033 .
  5. ↑ S. Cola Francesco et al .: Sjögren's syndrome: Another facet of the autoimmune / inflammatory syndrome induced by adjuvants (ASIA) . In: Journal of Autoimmunity (=  Sjögren's Syndrome: an autoimmune epithelitis ). tape 51 , June 1, 2014, p. 10–16 , doi : 10.1016 / j.jaut.2014.03.003 .
  6. ↑ David Hawkes et al .: Revisiting adverse reactions to vaccines: A critical appraisal of Autoimmune Syndrome Induced by Adjuvants (ASIA) . In: Journal of Autoimmunity . tape 59 , May 2015, p. 77-84 , doi : 10.1016 / j.jaut.2015.02.005 , PMID 25794485 .
  7. ^ A b F. Zepp: vaccination myths in pediatrics . In: Monthly Pediatrics . tape 166 , no. December 12 , 2018, p. 1114–1119 , doi : 10.1007 / s00112-018-0610-3 .
  8. ^ The Children's Hospital of Philadelphia: Vaccines and Autoimmune / Inflammatory Syndrome Induced by Adjuvants (ASIA). September 17, 2018, accessed October 22, 2019 .
  9. ↑ J.-P. Goullé and L. Grangeot-Keros: Aluminum and vaccines: Current state of knowledge . In: Médecine et Maladies Infectieuses . October 11, 2019, doi : 10.1016 / j.medmal.2019.09.012 .
  10. ↑ a b Rohan Ameratunga, Daman Langguth, David Hawkes: Perspective: Scientific and ethical concerns pertaining to animal models of autoimmune / autoinflammatory syndrome induced by adjuvants (ASIA) . In: Autoimmunity Reviews . tape 17 , no. 5 , May 2018, p. 435-439 , doi : 10.1016 / j.autrev.2017.11.033 , PMID 29526635 .
  11. ↑ Lamiae Grimaldi-Bensouda et al .: Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance . In: Journal of Autoimmunity . tape 79 , May 2017, p. 84–90 , doi : 10.1016 / j.jaut.2017.01.005 , PMID 28190705 .
  12. ^ Paul A. Offit : The HPV Vaccine and Autoimmunity: Reviewing the Research. In: Medscape . September 15, 2016, accessed on January 29, 2020 .
  13. ^ Dorit Rubinstein Reiss: Vaccine injury compensation and autoimmune syndromes. In: Skeptical Raptor. March 13, 2017, accessed January 29, 2020 (American English).
  14. ^ Safety update of HPV vaccines. WHO, January 22, 2016, accessed January 29, 2020 .
  15. ^ HPV vaccine adverse effects and the European Medicines Agency. In: Skeptical Raptor. September 5, 2018, accessed January 29, 2020 (American English).
  16. ↑ Doris Oberle et al .: Vaccination Complications and Dealing with Suspected Cases . In: Federal Health Gazette . tape 62 , no. 4 , April 1, 2019, ISSN  1437-1588 , p. 450-461 , doi : 10.1007 / s00103-019-02913-1 .