Autoinflammation

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Autoinflammation is an inflammatory response mediated by the innate immune system that appears to occur on its own. The term autoinflammation was first proposed in the late 1990s to refer to TRAPS syndrome , a periodic fever syndrome . The group of these fever syndromes are the main representatives of autoinflammatory diseases. Other diseases with autoinflammatory aspects are SJIA (Still's disease) , but diseases such as gout or type II diabetes mellitus are now being discussed.

mechanism

In contrast to classic autoimmune diseases , there are no specific autoantibodies or antigen-specific T lymphocytes , but overactivity of cells of the natural immune system . These are activated by local tissue-specific factors and cause tissue damage. The inflammasome reaction plays an essential role in the pathophysiology of autoinflammation .

Individual evidence

  1. ↑ McDermott et al .: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes . PMID 10199409 .
  2. ↑ T. Kallinich: Autoinflammatory Syndrome . In: N. Wagner, G. Dannecker (Ed.): Pediatric Rheumatology . 2nd Edition. Springer, Berlin Heidelberg 2014, ISBN 978-3-642-34727-6 , pp. 434 f .
  3. ↑ Autoinflammatory Diseases - Periodic Fever Syndromes. Retrieved August 28, 2016 .
  4. ↑ Dennis McGonagle, Michael F. McDermott: A proposed classification of the immunological diseases . In: PLoS medicine . tape 3 , no. 8 , August 2006, ISSN  1549-1676 , p. e297 , doi : 10.1371 / journal.pmed.0030297 , PMID 16942393 , PMC 1564298 (free full text).