BLIS (medicine)

BLIS ( English bacteriocin-like inhibitory substances , bacteriocin-like inhibitory substances ') are small proteinogenic toxins ( protein molecules ) with antibiotic properties that have an inhibitory effect similar to those produced by some types of bacteria (such as the so-called "good" streptococci Salivarius K12).

They can be useful against some types of streptococcus as part of bacterial replacement therapy by helping to prevent tooth decay and periodontal disease . They can also be useful for building up the intestinal flora after antibiotic or antifungal treatment.

See also

• Bacteriocins

literature

• JP Burton, CN Chilcott, JR Tagg: The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics . In: Oral Diseases . 11 Suppl 1, 2005, p. 29-31 , doi : 10.1111 / j.1601-0825.2005.01084.x , PMID 15752094 .
• JP Burton, CN Chilcott, CJ Moore, G Speiser, JR Tagg: A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters . In: Journal of Applied Microbiology . tape 100 , no. 4 , 2006, ISSN  1365-2672 , pp. 754-764 , doi : 10.1111 / j.1365-2672.2006.02837.x , PMID 16553730 .
• JP Burton, PA Wescombe, CJ Moore, CN Chilcott, JR Tagg: Safety Assessment of the Oral Cavity Probiotic Streptococcus salivarius K12 . In: Applied and Environmental Microbiology . tape 72 , no. 4 , 2017, ISSN  1098-5336 , p. 3050–3053 , doi : 10.1128 / AEM.72.4.3050-3053.2006 , PMC 1449041 (free full text).
• H.-P. Horz, A. Meinelt, B. Houben, G. Conrads: Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction . In: Oral Microbiology and Immunology . tape 22 , no. 2 , 2007, ISSN  2041-1014 , p. 126-130 , doi : 10.1111 / j.1399-302X.2007.00334.x , PMID 17311636 .
• A. Meinelt: Molecular methods for the detection of the oral probiotic strain Streptococcus salivarius ssp. salivarius K12 and application in vitro and in vivo . Aachen 2006, DNB  981329160 , urn : nbn: de: hbz: 82-opus-15614 (dissertation).