Bliss independence

The Bliss independence (to German, according to Bliss independence ') is a model describing the dependence of the effects of two agents from one another. Other models are e.g. B. the Loewe additivity .

properties

The bliss independence describes the additive effect of two active ingredients with different modes of action. Assuming an effect that is largely independent of the concentration of the other active ingredient, two analogues of a certain effective concentration have the following effect with different sites and mechanisms of action :

E _{1 + 2} = E ₁ + E ₂ - E ₁ E ₂

Web links

BfR: Multiple residues from the perspective of different interest groups (PDF; 204 kB), 2005. Accessed on August 22, 2013.

Individual evidence

^ CI Bliss: The toxicity of poisons applied jointly. In: Ann Appl Biol (1939), vol. 26, pp. 585-615. doi : 10.1111 / j.1744-7348.1939.tb06990.x .
↑ PJ Yeh, MJ Hegreness, AP Aiden, R. Kishony: Drug interactions and the evolution of antibiotic resistance. In: Nat Rev Microbiol. (2009), Volume 7, No. 6, pp. 460-466. doi : 10.1038 / nrmicro2133 . PMID 19444248 ; PMC 2855488 (free full text).

[1] CI Bliss: The toxicity of poisons applied jointly. In: Ann Appl Biol (1939), vol. 26, pp. 585-615. doi : 10.1111 / j.1744-7348.1939.tb06990.x .

[2] PJ Yeh, MJ Hegreness, AP Aiden, R. Kishony: Drug interactions and the evolution of antibiotic resistance. In: Nat Rev Microbiol. (2009), Volume 7, No. 6, pp. 460-466. doi : 10.1038 / nrmicro2133 . PMID 19444248 ; PMC 2855488 (free full text).