Loewe additivity

The Loewe additivity (engl. Loewe additivity ) is a model describing the dependence of the effects of two agents from one another. Other models are e.g. B. Bliss independence (in German 'Independence according to Bliss').

properties

Loewe additivity describes the additive effect of two active ingredients with the same mode of action. Assuming an effect that is largely independent of its own concentration, two analogues of a certain effective concentration have the same effect as only one of them in double the dose, given the same site and mechanism of action .

c ₁ EC ₁⁻¹ + c ₂ EC ₂⁻¹ = 1

Web links

BfR: Multiple residues from the perspective of different interest groups (PDF; 204 kB), 2005. Accessed on August 22, 2013.

Individual evidence

↑ S. Loewe, H. Muischnek: About combination effects . 1st communication: Aids to the question. In: Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol (1926), Volume 114, pp. 313-326. doi : 10.1007 / BF01952257 .

↑ PJ Yeh, MJ Hegreness, AP Aiden, R. Kishony: Drug interactions and the evolution of antibiotic resistance. In: Nat Rev Microbiol. (2009), Volume 7, No. 6, pp. 460-466. doi : 10.1038 / nrmicro2133 . PMID 19444248 ; PMC 2855488 (free full text).

↑ J. Jack Lee and Maiying Kong: Rebuttal to the response of Chou. In: Cancer Research (2011), Vol. 71, pp. 2798-2800. doi : 10.1158 / 0008-5472.CAN-11-0382 . PDF .

[1] S. Loewe, H. Muischnek: About combination effects . 1st communication: Aids to the question. In: Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol (1926), Volume 114, pp. 313-326. doi : 10.1007 / BF01952257 .

[2] PJ Yeh, MJ Hegreness, AP Aiden, R. Kishony: Drug interactions and the evolution of antibiotic resistance. In: Nat Rev Microbiol. (2009), Volume 7, No. 6, pp. 460-466. doi : 10.1038 / nrmicro2133 . PMID 19444248 ; PMC 2855488 (free full text).

[3] J. Jack Lee and Maiying Kong: Rebuttal to the response of Chou. In: Cancer Research (2011), Vol. 71, pp. 2798-2800. doi : 10.1158 / 0008-5472.CAN-11-0382 . PDF .