Bohlmann-Rahtz synthesis
The Bohlmann-Rahtz synthesis is a name reaction in organic chemistry . The reaction is named after its discoverers, the German chemists Ferdinand Bohlmann (1921–1991) and Dieter Rahtz.
A 3-aminocrotonic acid ester (e.g. 1 ) is either a
- Alkynyl alkyl ketone 2a added or with one
- β-diketone 2b converted to intermediate 3 with elimination of water :
The open-chain compound 3 cyclizes on heating with elimination of water and aromatization to the substituted ester 4 of nicotinic acid .
Individual evidence
- ^ Theophil Eicher , Siegfried Hauptmann , Andreas Speicher: The Chemistry of Heterocycles , Wiley-VCH, 2012, ISBN 978-3-527-32747-8 , p. 369.