CD1a

T-cell surface glycoprotein CD1a
	according to PDB 1ONQ , in 2 views
other names	T-cell surface antigen T6 / Leu-6, hTa1 thymocyte antigen
	Existing structure data : PDB 1XZ0 , PDB 4X6C
Properties of human protein
Mass / length primary structure	327 amino acids , 37,077 Da
Identifier
External IDs	GeneCards : CD1A ; UniProt : P06126 ;

T-cell surface glycoprotein CD1a is a surface protein .

properties

It is among others in cortical thymocytes , Langerhans cells , dendritic cells , in some T cell leukemias formed. CD1a is in the course of the adaptive immune response involved in the antigen presentation of lipid -, lipopeptide - and glycolipid - antigens compared to the T cell receptor of the NKT cells . In addition to lipids, it also binds to beta-2 microglobulin . CD1a is glycosylated and has disulfide bridges .

It can be used as an immunohistochemical examination in histiocytosis X in order to be able to detect thymocytes, Langerhans cells and dendritic cells.

Web links

MeSH CD1a

Individual evidence

^ I. Van Rhijn, D. Ly, DB Moody: CD1a, CD1b, and CD1c in immunity against mycobacteria. In: Advances in Experimental Medicine and Biology . Volume 783, 2013, pp. 181-197, doi : 10.1007 / 978-1-4614-6111-1_10 , PMID 23468110 .

[1] I. Van Rhijn, D. Ly, DB Moody: CD1a, CD1b, and CD1c in immunity against mycobacteria. In: Advances in Experimental Medicine and Biology . Volume 783, 2013, pp. 181-197, doi : 10.1007 / 978-1-4614-6111-1_10 , PMID 23468110 .